| Literature DB >> 15144871 |
F Blandini1, M T Armentero, R Fancellu, E Blaugrund, G Nappi.
Abstract
Sprague-Dawley rats received a unilateral injection of 6-hydroxydopamine (6-OHDA) into the striatum and were treated daily for 6 weeks with increasing doses of monoamine oxidase type B inhibitor rasagiline [R(+)-N-propargyl-1-aminoindane] or saline (controls). Both doses of rasagiline markedly increased the survival of dopaminergic neurons in the lesioned substantia nigra, compared to controls (+97% and +119%, respectively). Treatment with the lower dose of rasagiline also abolished the motor stereotypies associated with nigrostriatal lesion. Our study supports the neuroprotective potential of chronic rasagiline administration in an experimental model of Parkinson's disease (PD).Entities:
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Year: 2004 PMID： 15144871 DOI： 10.1016/j.expneurol.2004.03.005
Source DB: PubMed Journal: Exp Neurol ISSN： 0014-4886 Impact factor: 5.330