BACKGROUND: Asthma is a genetically complex disease characterized by respiratory symptoms, intermittent airway obstruction and airway hyper-responsiveness due to airway inflammation and remodelling. The ADAM33 gene is associated with asthma and airway hyper-responsiveness and is postulated as a gene for airway remodelling. OBJECTIVE: To investigate whether polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in patients with asthma. METHODS: In a cohort of 200 asthma patients followed over 20 years, eight single nucleotide polymorphisms of the ADAM33 gene were analysed to estimate their effect on annual FEV(1) decline. RESULTS: The rare allele of the S_2 polymorphism was significantly associated with excess decline in FEV(1) (P<0.05). CONCLUSION: These findings suggest that a variant in ADAM33 is not only important in the development of asthma but also in disease progression, possibly related to enhanced airway remodelling.
BACKGROUND:Asthma is a genetically complex disease characterized by respiratory symptoms, intermittent airway obstruction and airway hyper-responsiveness due to airway inflammation and remodelling. The ADAM33 gene is associated with asthma and airway hyper-responsiveness and is postulated as a gene for airway remodelling. OBJECTIVE: To investigate whether polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in patients with asthma. METHODS: In a cohort of 200 asthmapatients followed over 20 years, eight single nucleotide polymorphisms of the ADAM33 gene were analysed to estimate their effect on annual FEV(1) decline. RESULTS: The rare allele of the S_2 polymorphism was significantly associated with excess decline in FEV(1) (P<0.05). CONCLUSION: These findings suggest that a variant in ADAM33 is not only important in the development of asthma but also in disease progression, possibly related to enhanced airway remodelling.
Authors: Antoon Dijkstra; Dirkje S Postma; Jacobien A Noordhoek; Monique E Lodewijk; Henk F Kauffman; Nick H T ten Hacken; Wim Timens Journal: Virchows Arch Date: 2009-03-03 Impact factor: 4.064
Authors: Joanna Smolonska; Gerard H Koppelman; Cisca Wijmenga; Judith M Vonk; Pieter Zanen; Marcel Bruinenberg; Ivan Curjuric; Medea Imboden; Gian-Andri Thun; Lude Franke; Nicole M Probst-Hensch; Peter Nürnberg; Roland A Riemersma; Constant P van Schayck; Daan W Loth; Guy G Brusselle; Bruno H Stricker; Albert Hofman; André G Uitterlinden; Lies Lahousse; Stephanie J London; Laura R Loehr; Ani Manichaikul; R Graham Barr; Kathleen M Donohue; Stephen S Rich; Peter Pare; Yohan Bossé; Ke Hao; Maarten van den Berge; Harry J M Groen; Jan-Willem J Lammers; Willem Mali; H Marike Boezen; Dirkje S Postma Journal: Eur Respir J Date: 2014-07-03 Impact factor: 16.671