| Literature DB >> 15143210 |
John G McCarron1, Karen N Bradley, Debbi MacMillan, Susan Chalmers, Thomas C Muir.
Abstract
The sarcoplasmic reticulum (SR) and apposed regions of the sarcolemma passively trap Ca2+ entering the cell to limit the rise in cytoplasmic Ca2+ concentration without SR pump involvement. When "leaky," the SR facilitates Ca2+ entry to the cytoplasm. SR Ca2+ release via inositol 1,4,5-trisphosphate receptors (IP(3)Rs) propagates as calcium waves; IP(3)Rs alone account for wave propagation.Entities:
Mesh:
Substances:
Year: 2004 PMID: 15143210 DOI: 10.1152/nips.01518.2004
Source DB: PubMed Journal: News Physiol Sci ISSN: 0886-1714