Literature DB >> 15143203

Use of recombinant congenic strains in mapping disease-modifying genes.

Jana Müllerová1, Pavel Hozák.   

Abstract

Previous research studies have established much information about single-gene diseases. However, other genes also influencing the outcome of a disease and genes involved in complex disease remain largely unknown. Here we report on recombinant congenic strains of mice, a powerful tool for genetic dissection of a complex trait.

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Year:  2004        PMID： 15143203     DOI： 10.1152/nips.01512.2003

Source DB:  PubMed          Journal:  News Physiol Sci        ISSN： 0886-1714


  6 in total

1.  No gene is an island: the flip-flop phenomenon.

Authors:  Ping-I Lin; Jeffery M Vance; Margaret A Pericak-Vance; Eden R Martin
Journal:  Am J Hum Genet       Date:  2007-01-22       Impact factor: 11.025

Review 2.  Host resistance to malaria: using mouse models to explore the host response.

Authors:  Rhea Longley; Clare Smith; Anny Fortin; Joanne Berghout; Brendan McMorran; Gaétan Burgio; Simon Foote; Philippe Gros
Journal:  Mamm Genome       Date:  2010-11-30       Impact factor: 2.957

Review 3.  Harnessing preclinical mouse models to inform human clinical cancer trials.

Authors:  David H Gutmann; Kim Hunter-Schaedle; Kevin M Shannon
Journal:  J Clin Invest       Date:  2006-04       Impact factor: 14.808

4.  Strain-specific differences in the genetic control of two closely related mycobacteria.

Authors:  Tania Di Pietrantonio; Carmen Hernandez; Manon Girard; Annie Verville; Marianna Orlova; Adam Belley; Marcel A Behr; J Concepción Loredo-Osti; Erwin Schurr
Journal:  PLoS Pathog       Date:  2010-10-28       Impact factor: 6.823

5.  The trace amine associated receptor (TAAR6) gene is not associated with schizophrenia in the Irish Case-Control Study of Schizophrenia (ICCSS) sample.

Authors:  Vladimir I Vladimirov; Brion S Maher; Brandon Wormley; F Anthony O'Neill; Dermot Walsh; Kenneth S Kendler; Brien P Riley
Journal:  Schizophr Res       Date:  2008-10-30       Impact factor: 4.939

6.  A cautionary note on ignoring polygenic background when mapping quantitative trait loci via recombinant congenic strains.

Authors:  J Concepción Loredo-Osti
Journal:  Front Genet       Date:  2014-04-02       Impact factor: 4.599
  6 in total

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