Literature DB >> 15143200

How free fatty acids inhibit glucose utilization in human skeletal muscle.

Michael Roden1.   

Abstract

Rat muscle studies suggest competition between free fatty acids (FFA) and glucose for oxidation, resulting in glucose-6-phosphate accumulation. However, FFA decrease glucose-6-phosphate in human skeletal muscle, indicating direct inhibition of glucose transport/phosphorylation. This mechanism could redirect glucose from muscle to brain during fasting and explain the insulin resistance associated with high-lipid diets and obesity.

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Year:  2004        PMID： 15143200     DOI： 10.1152/nips.01459.2003

Source DB:  PubMed          Journal:  News Physiol Sci        ISSN： 0886-1714


  50 in total

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