| Literature DB >> 15142757 |
T Alarcón1, H M Byrne, P K Maini.
Abstract
Multiscale approaches to modelling biological phenomena are growing rapidly. We present here some recent results on the formulation of a theoretical framework which can be developed into a fully integrative model for cancer growth. The model takes account of vascular adaptation and cell-cycle dynamics. We explore the effects of spatial inhomogeneity induced by the blood flow through the vascular network and of the possible effects of p27 on the cell cycle. We show how the model may be used to investigate the efficiency of drug-delivery protocols. Copyright 2004 Elsevier Ltd.Entities:
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Year: 2004 PMID： 15142757 DOI： 10.1016/j.pbiomolbio.2004.02.004
Source DB: PubMed Journal: Prog Biophys Mol Biol ISSN： 0079-6107 Impact factor: 3.667