Literature DB >> 15142618

In vitro assays for evaluation of drug activity against Leishmania spp.

Luciana Fumarola1, Rosa Spinelli, Olga Brandonisio.   

Abstract

Leishmania is a parasitic protozoan which causes severe disease in humans and dogs. Screening of new compounds against leishmaniasis is particularly needed to determine the toxicity of some existing drugs and the appearance of drug-resistant strains. Reliable and simple in vitro models are required for large-scale initial screenings. In this review different methods for in vitro evaluation of drug activity against Leishmania spp. are summarized.

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Year:  2004        PMID： 15142618     DOI： 10.1016/j.resmic.2004.01.001

Source DB:  PubMed          Journal:  Res Microbiol        ISSN： 0923-2508            Impact factor:   3.992


  35 in total

1.  Development of an ex vivo lymph node explant model for identification of novel molecules active against Leishmania major.

Authors:  Alex G Peniche; Yaneth Osorio; Adam R Renslo; Doug E Frantz; Peter C Melby; Bruno L Travi
Journal:  Antimicrob Agents Chemother       Date:  2013-10-14       Impact factor: 5.191

2.  Achievement amastigotes of Leishmania infantum and investigation of pathological changes in the tissues of infected golden hamsters.

Authors:  Sajad Rashidi; Kurosh Kalantar; Gholamreza Hatam
Journal:  J Parasit Dis       Date:  2018-03-05

Review 3.  Imaging flow cytometry analysis of intracellular pathogens.

Authors:  Viraga Haridas; Shahin Ranjbar; Ivan A Vorobjev; Anne E Goldfeld; Natasha S Barteneva
Journal:  Methods       Date:  2016-09-15       Impact factor: 3.608

Review 4.  Antileishmanial and Immunomodulatory Activity of Allium sativum (Garlic): A Review.

Authors:  Masoud Foroutan-Rad; Khosrow Hazrati Tappeh; Shahram Khademvatan
Journal:  J Evid Based Complementary Altern Med       Date:  2015-12-30

5.  In vitro screening test using Leishmania promastigotes stably expressing mCherry protein.

Authors:  Paola Vacchina; Miguel A Morales
Journal:  Antimicrob Agents Chemother       Date:  2014-01-06       Impact factor: 5.191

6.  A novel Leishmania major amastigote assay in 96-well format for rapid drug screening and its use for discovery and evaluation of a new class of leishmanicidal quinolinium salts.

Authors:  Gerhard Bringmann; Katja Thomale; Sebastian Bischof; Christoph Schneider; Martina Schultheis; Tobias Schwarz; Heidrun Moll; Uta Schurigt
Journal:  Antimicrob Agents Chemother       Date:  2013-04-15       Impact factor: 5.191

7.  In vitro antileishmanial drug susceptibility of clinical isolates from patients with Indian visceral leishmaniasis--status of newly introduced drugs.

Authors:  Vijay Kumar Prajapati; Sanjana Mehrotra; Shalini Gautam; Madhukar Rai; Shyam Sundar
Journal:  Am J Trop Med Hyg       Date:  2012-08-27       Impact factor: 2.345

8.  Isopropyl quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives induce regulated necrosis-like cell death on Leishmania (Leishmania) mexicana.

Authors:  Karla Fabiola Chacón-Vargas; Sergio Andrade-Ochoa; Benjamín Nogueda-Torres; Dulce Carolina Juárez-Ramírez; Edgar E Lara-Ramírez; Ricardo Mondragón-Flores; Antonio Monge; Gildardo Rivera; Luvia Enid Sánchez-Torres
Journal:  Parasitol Res       Date:  2017-11-20       Impact factor: 2.289

9.  Antileishmanial activity of a naphthoquinone derivate against promastigote and amastigote stages of Leishmania infantum and Leishmania amazonensis and its mechanism of action against L. amazonensis species.

Authors:  Débora Vasconcelos Costa Mendonça; Daniela Pagliara Lage; Stephane Lima Calixto; Flaviano Melo Ottoni; Grasiele de Sousa Vieira Tavares; Fernanda Ludolf; Miguel Angel Chávez-Fumagalli; Mônica Santos Schneider; Mariana Costa Duarte; Carlos Alberto Pereira Tavares; Ricardo José Alves; Elaine Soares Coimbra; Eduardo Antonio Ferraz Coelho
Journal:  Parasitol Res       Date:  2017-12-16       Impact factor: 2.289

10.  In vitro susceptibilities of Leishmania donovani promastigote and amastigote stages to antileishmanial reference drugs: practical relevance of stage-specific differences.

Authors:  Marieke Vermeersch; Raquel Inocêncio da Luz; Kim Toté; Jean-Pierre Timmermans; Paul Cos; Louis Maes
Journal:  Antimicrob Agents Chemother       Date:  2009-06-22       Impact factor: 5.191
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