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Literature DB >> 15142520

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Abstract

The establishment and maintenance of immunological tolerance entails both central and peripheral mechanisms. The latter have been highlighted in the past several years, mostly because of great interest in the activities of regulatory T cells. However, an important role for central tolerance mechanisms has been reemphasized by recent results on human autoimmune diseases, including APECED and type 1 diabetes.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2004 PMID： 15142520 DOI： 10.1016/s1074-7613(04)00111-6

Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745

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Cited

63 in total

1. High intrafamilial variability in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy: a case study.

Authors: D Capalbo; A Fusco; G Aloj; N Improda; L Vitiello; U Dianzani; C Betterle; M Salerno; C Pignata
Journal: J Endocrinol Invest Date: 2011-11-07 Impact factor: 4.256

2. Genes mediating environment interactions in type 1 diabetes.

Authors: Erik Biros; Margaret A Jordan; Alan G Baxter
Journal: Rev Diabet Stud Date: 2006-02-10

Review 3. Antigen presentation by monocytes and monocyte-derived cells.

Authors: Gwendalyn J Randolph; Claudia Jakubzick; Chunfeng Qu
Journal: Curr Opin Immunol Date: 2007-12-21 Impact factor: 7.486

Review 4. Analogies in the evolution of individual and social immunity.

Authors: Sylvia Cremer; Michael Sixt
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2009-01-12 Impact factor: 6.237

5. Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell development.

Authors: Weiming Ouyang; Omar Beckett; Qian Ma; Ming O Li
Journal: Immunity Date: 2010-05-13 Impact factor: 31.745

6. Regulatory T cell differentiation of thymocytes does not require a dedicated antigen-presenting cell but is under T cell-intrinsic developmental control.

Authors: Gerald Wirnsberger; Florian Mair; Ludger Klein
Journal: Proc Natl Acad Sci U S A Date: 2009-06-10 Impact factor: 11.205

Back to central tolerance.

1. High intrafamilial variability in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy: a case study.

2. Genes mediating environment interactions in type 1 diabetes.

Review 3. Antigen presentation by monocytes and monocyte-derived cells.

Review 4. Analogies in the evolution of individual and social immunity.

5. Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell development.

6. Regulatory T cell differentiation of thymocytes does not require a dedicated antigen-presenting cell but is under T cell-intrinsic developmental control.

7. Mechanisms of malignant glioma immune resistance and sources of immunosuppression.

8. How defects in central tolerance impinge on a deficiency in regulatory T cells.

Review 9. Type 1 diabetes: translating mechanistic observations into effective clinical outcomes.

10. Regulation of medullary thymic epithelial cell differentiation and function by the signaling protein Sin.