Literature DB >> 15141375

Using tissue adjacent to carcinoma as a normal control: an obvious but questionable practice.

Boudewijn J M Braakhuis1, C René Leemans, Ruud H Brakenhoff.   

Abstract

When carcinoma tissue is investigated using biochemical, immunohistochemical, and genetic techniques, adjacent tissue that is macroscopically normal is frequently used as a control, since cancer-related pheno- and geno-typic alterations are assumed to be absent. However, a field that contains genetically abnormal cells surrounds a significant proportion of carcinomas (for example, over 30% of head and neck cancers). These fields can be large (>7 cm in diameter) and consist of cells that are clonally related to the carcinoma. This indicates that adjacent epithelium must be checked for genetic abnormalities before it is considered normal and used as a control for comparison with carcinoma. Copyright 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

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Year:  2004        PMID： 15141375     DOI： 10.1002/path.1549

Source DB:  PubMed          Journal:  J Pathol        ISSN： 0022-3417            Impact factor:   7.996


  18 in total

1.  Global detection of molecular changes reveals concurrent alteration of several biological pathways in nonsmall cell lung cancer cells.

Authors:  Z Ju; M Kapoor; K Newton; K Cheon; A Ramaswamy; R Lotan; L C Strong; J S Koo
Journal:  Mol Genet Genomics       Date:  2005-10-11       Impact factor: 3.291

2.  Early growth response 1 and fatty acid synthase expression is altered in tumor adjacent prostate tissue and indicates field cancerization.

Authors:  Anna C Jones; Kristina A Trujillo; Genevieve K Phillips; Trisha M Fleet; Jaclyn K Murton; Virginia Severns; Satyan K Shah; Michael S Davis; Anthony Y Smith; Jeffrey K Griffith; Edgar G Fischer; Marco Bisoffi
Journal:  Prostate       Date:  2011-11-29       Impact factor: 4.104

3.  Expression profiling and prediction of distant metastases in head and neck squamous cell carcinoma.

Authors:  B J M Braakhuis; A Senft; R de Bree; J de Vries; B Ylstra; J Cloos; D J Kuik; C R Leemans; R H Brakenhoff
Journal:  J Clin Pathol       Date:  2006-05-05       Impact factor: 3.411

4.  Comparison of lung cancer cell lines representing four histopathological subtypes with gene expression profiling using quantitative real-time PCR.

Authors:  Takashi Watanabe; Tomohiro Miura; Yusuke Degawa; Yuna Fujita; Masaaki Inoue; Makoto Kawaguchi; Chie Furihata
Journal:  Cancer Cell Int       Date:  2010-01-21       Impact factor: 5.722

5.  Integrated genomic and transcriptional profiling identifies chromosomal loci with altered gene expression in cervical cancer.

Authors:  Saskia M Wilting; Jillian de Wilde; Chris J L M Meijer; Johannes Berkhof; Yajun Yi; Wessel N van Wieringen; Boudewijn J M Braakhuis; Gerrit A Meijer; Bauke Ylstra; Peter J F Snijders; Renske D M Steenbergen
Journal:  Genes Chromosomes Cancer       Date:  2008-10       Impact factor: 5.006

6.  Markers of field cancerization: proposed clinical applications in prostate biopsies.

Authors:  Kristina A Trujillo; Anna C Jones; Jeffrey K Griffith; Marco Bisoffi
Journal:  Prostate Cancer       Date:  2012-05-14

7.  Novel long non-coding RNAs are specific diagnostic and prognostic markers for prostate cancer.

Authors:  René Böttcher; A Marije Hoogland; Natasja Dits; Esther I Verhoef; Charlotte Kweldam; Piotr Waranecki; Chris H Bangma; Geert J L H van Leenders; Guido Jenster
Journal:  Oncotarget       Date:  2015-02-28

8.  Novel cancerization marker, TP53, and its role in distinguishing normal tissue adjacent to cancerous tissue from normal tissue adjacent to benign tissue.

Authors:  Guo-Yan Liu; Kun-Hong Liu; Yin Li; Chao Pan; Ji-Qin Su; Hong-Feng Liao; Ren-Xiang Yv; Zhao-Hui Li; Li Yuan; Huan-Jing Zhang; Chi-Meng Tzeng; Bing Xiong
Journal:  World J Surg Oncol       Date:  2012-11-21       Impact factor: 2.754

9.  Clinical implications and utility of field cancerization.

Authors:  Gabriel D Dakubo; John P Jakupciak; Mark A Birch-Machin; Ryan L Parr
Journal:  Cancer Cell Int       Date:  2007-03-15       Impact factor: 5.722

10.  Prostate field cancerization: deregulated expression of macrophage inhibitory cytokine 1 (MIC-1) and platelet derived growth factor A (PDGF-A) in tumor adjacent tissue.

Authors:  Anna C Jones; Kresta S Antillon; Shannon M Jenkins; Sara N Janos; Heidi N Overton; Dor S Shoshan; Edgar G Fischer; Kristina A Trujillo; Marco Bisoffi
Journal:  PLoS One       Date:  2015-03-13       Impact factor: 3.240
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