Literature DB >> 15141004

CD40-associated TRAF 6 signaling is required for disease induction in a retrovirus-induced murine immunodeficiency.

Kathy A Green1, Cory L Ahonen, W James Cook, William R Green.   

Abstract

LP-BM5 retrovirus-infected C57BL/6 mice develop splenomegaly, lymphadenopathy, hypergammaglobulinemia, and immunodeficiency; thus, this disease has been named mouse AIDS. In this syndrome, CD154/CD40 interactions are required for but do not mediate disease by upregulation of CD80 or CD86. We report here that there is nonetheless a necessity for CD40 signaling competence, specifically an intact tumor necrosis factor receptor-associated factor 6 (TRAF 6) binding site.

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Year:  2004        PMID： 15141004      PMCID： PMC415804          DOI： 10.1128/JVI.78.11.6055-6060.2004

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  40 in total

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Journal:  Cell Immunol       Date:  1996-11-25       Impact factor: 4.868

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Journal:  J Virol       Date:  1997-04       Impact factor: 5.103

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Journal:  Nature       Date:  1989-04-06       Impact factor: 49.962

4.  Antibody to the ligand for CD40 (gp39) inhibits murine AIDS-associated splenomegaly, hypergammaglobulinemia, and immunodeficiency in disease-susceptible C57BL/6 mice.

Authors:  K A Green; K M Crassi; J D Laman; A Schoneveld; R R Strawbridge; T M Foy; R J Noelle; W R Green
Journal:  J Virol       Date:  1996-04       Impact factor: 5.103

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Authors:  Z Cao; J Xiong; M Takeuchi; T Kurama; D V Goeddel
Journal:  Nature       Date:  1996-10-03       Impact factor: 49.962

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Journal:  J Virol       Date:  1994-09       Impact factor: 5.103

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Journal:  Immunity       Date:  1994-06       Impact factor: 31.745

8.  Studies on the interdependence of gp39 and B7 expression and function during antigen-specific immune responses.

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Journal:  Eur J Immunol       Date:  1995-02       Impact factor: 5.532

9.  Assembly and regulation of the CD40 receptor complex in human B cells.

Authors:  M R Kuhné; M Robbins; J E Hambor; M F Mackey; Y Kosaka; T Nishimura; J P Gigley; R J Noelle; D M Calderhead
Journal:  J Exp Med       Date:  1997-07-21       Impact factor: 14.307

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Authors:  E A Ranheim; T J Kipps
Journal:  J Exp Med       Date:  1993-04-01       Impact factor: 14.307
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  7 in total

1.  Murine AIDS requires CD154/CD40L expression by the CD4 T cells that mediate retrovirus-induced disease: Is CD4 T cell receptor ligation needed?

Authors:  Wen Li; William R Green
Journal:  Virology       Date:  2006-11-17       Impact factor: 3.616

2.  Myeloid-derived suppressor cells in murine AIDS inhibit B-cell responses in part via soluble mediators including reactive oxygen and nitrogen species, and TGF-β.

Authors:  Jessica L Rastad; William R Green
Journal:  Virology       Date:  2016-09-12       Impact factor: 3.616

3.  The role of CD4 T cells in the pathogenesis of murine AIDS.

Authors:  Wen Li; William R Green
Journal:  J Virol       Date:  2006-06       Impact factor: 5.103

4.  Role of a cytotoxic-T-lymphocyte epitope-defined, alternative gag open reading frame in the pathogenesis of a murine retrovirus-induced immunodeficiency syndrome.

Authors:  Arti Gaur; William R Green
Journal:  J Virol       Date:  2005-04       Impact factor: 5.103

5.  Immunotherapy of murine retrovirus-induced acquired immunodeficiency by CD4 T regulatory cell depletion and PD-1 blockade.

Authors:  Wen Li; William R Green
Journal:  J Virol       Date:  2011-09-14       Impact factor: 5.103

6.  Myeloid-derived suppressor cells in murine retrovirus-induced AIDS inhibit T- and B-cell responses in vitro that are used to define the immunodeficiency.

Authors:  Kathy A Green; W James Cook; William R Green
Journal:  J Virol       Date:  2012-12-05       Impact factor: 5.103

7.  The programmed death-1 and interleukin-10 pathways play a down-modulatory role in LP-BM5 retrovirus-induced murine immunodeficiency syndrome.

Authors:  Kathy A Green; Taku Okazaki; Tasuku Honjo; W James Cook; William R Green
Journal:  J Virol       Date:  2007-12-19       Impact factor: 5.103
  7 in total

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