Literature DB >> 15141003

Cleavage inhibition of the murine coronavirus spike protein by a furin-like enzyme affects cell-cell but not virus-cell fusion.

Cornelis A M de Haan1, Konrad Stadler, Gert-Jan Godeke, Berend Jan Bosch, Peter J M Rottier.   

Abstract

Cleavage of the mouse hepatitis coronavirus strain A59 spike protein was blocked in a concentration-dependent manner by a peptide furin inhibitor, indicating that furin or a furin-like enzyme is responsible for this process. While cell-cell fusion was clearly affected by preventing spike protein cleavage, virus-cell fusion was not, indicating that these events have different requirements.

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Year:  2004        PMID： 15141003      PMCID： PMC415802          DOI： 10.1128/JVI.78.11.6048-6054.2004

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  47 in total

1.  Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen.

Authors:  S S Molloy; P A Bresnahan; S H Leppla; K R Klimpel; G Thomas
Journal:  J Biol Chem       Date:  1992-08-15       Impact factor: 5.157

2.  Alteration of the pH dependence of coronavirus-induced cell fusion: effect of mutations in the spike glycoprotein.

Authors:  T M Gallagher; C Escarmis; M J Buchmeier
Journal:  J Virol       Date:  1991-04       Impact factor: 5.103

3.  Assembly of spikes into coronavirus particles is mediated by the carboxy-terminal domain of the spike protein.

Authors:  G J Godeke; C A de Haan; J W Rossen; H Vennema; P J Rottier
Journal:  J Virol       Date:  2000-02       Impact factor: 5.103

Review 4.  Processing of protein precursors by a novel family of subtilisin-related mammalian endoproteases.

Authors:  S P Smeekens
Journal:  Biotechnology (N Y)       Date:  1993-02

5.  Fusion-defective mutants of mouse hepatitis virus A59 contain a mutation in the spike protein cleavage signal.

Authors:  J L Gombold; S T Hingley; S R Weiss
Journal:  J Virol       Date:  1993-08       Impact factor: 5.103

6.  Proteolytic cleavage of the murine coronavirus surface glycoprotein is not required for fusion activity.

Authors:  R Stauber; M Pfleiderera; S Siddell
Journal:  J Gen Virol       Date:  1993-02       Impact factor: 3.891

7.  Characterization of a secreted form of human furin endoprotease.

Authors:  G Vidricaire; J B Denault; R Leduc
Journal:  Biochem Biophys Res Commun       Date:  1993-09-15       Impact factor: 3.575

8.  Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation.

Authors:  L H Wang; K G Rothberg; R G Anderson
Journal:  J Cell Biol       Date:  1993-12       Impact factor: 10.539

9.  Enhancement of the vaccinia virus/phage T7 RNA polymerase expression system using encephalomyocarditis virus 5'-untranslated region sequences.

Authors:  H Vennema; R Rijnbrand; L Heijnen; M C Horzinek; W J Spaan
Journal:  Gene       Date:  1991-12-15       Impact factor: 3.688

10.  Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface.

Authors:  S S Molloy; L Thomas; J K VanSlyke; P E Stenberg; G Thomas
Journal:  EMBO J       Date:  1994-01-01       Impact factor: 11.598
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  84 in total

1.  The coronavirus spike protein induces endoplasmic reticulum stress and upregulation of intracellular chemokine mRNA concentrations.

Authors:  Gijs A Versteeg; Paula S van de Nes; Peter J Bredenbeek; Willy J M Spaan
Journal:  J Virol       Date:  2007-08-01       Impact factor: 5.103

2.  Key Golgi factors for structural and functional maturation of bunyamwera virus.

Authors:  Reyes R Novoa; Gloria Calderita; Pilar Cabezas; Richard M Elliott; Cristina Risco
Journal:  J Virol       Date:  2005-09       Impact factor: 5.103

3.  Conformational states of the severe acute respiratory syndrome coronavirus spike protein ectodomain.

Authors:  Fang Li; Marcelo Berardi; Wenhui Li; Michael Farzan; Philip R Dormitzer; Stephen C Harrison
Journal:  J Virol       Date:  2006-07       Impact factor: 5.103

Review 4.  The molecular biology of coronaviruses.

Authors:  Paul S Masters
Journal:  Adv Virus Res       Date:  2006       Impact factor: 9.937

5.  Cooperative involvement of the S1 and S2 subunits of the murine coronavirus spike protein in receptor binding and extended host range.

Authors:  Cornelis A M de Haan; Eddie Te Lintelo; Zhen Li; Matthijs Raaben; Tom Wurdinger; Berend Jan Bosch; Peter J M Rottier
Journal:  J Virol       Date:  2006-09-06       Impact factor: 5.103

Review 6.  The novel human coronaviruses NL63 and HKU1.

Authors:  Krzysztof Pyrc; Ben Berkhout; Lia van der Hoek
Journal:  J Virol       Date:  2006-11-01       Impact factor: 5.103

7.  Neurovirulent Murine Coronavirus JHM.SD Uses Cellular Zinc Metalloproteases for Virus Entry and Cell-Cell Fusion.

Authors:  Judith M Phillips; Tom Gallagher; Susan R Weiss
Journal:  J Virol       Date:  2017-03-29       Impact factor: 5.103

8.  Identification and characterization of a proteolytically primed form of the murine coronavirus spike proteins after fusion with the target cell.

Authors:  Oliver Wicht; Christine Burkard; Cornelis A M de Haan; Frank J M van Kuppeveld; Peter J M Rottier; Berend Jan Bosch
Journal:  J Virol       Date:  2014-02-19       Impact factor: 5.103

9.  Dynamics of coronavirus replication-transcription complexes.

Authors:  Marne C Hagemeijer; Monique H Verheije; Mustafa Ulasli; Indra A Shaltiël; Lisa A de Vries; Fulvio Reggiori; Peter J M Rottier; Cornelis A M de Haan
Journal:  J Virol       Date:  2009-12-09       Impact factor: 5.103

10.  Cathepsin L functionally cleaves the severe acute respiratory syndrome coronavirus class I fusion protein upstream of rather than adjacent to the fusion peptide.

Authors:  Berend Jan Bosch; Willem Bartelink; Peter J M Rottier
Journal:  J Virol       Date:  2008-06-18       Impact factor: 5.103
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