Manola Comar1, Gianna Dal Molin, Secondo Guaschino, Cesare Campello. 1. Department of Public Medicine Sciences, U.C.O. Hygiene and Preventive Medicine, University of Trieste, I.R.C.C.S. Burlo Garofolo, Via dell'Istria 65/1, Trieste 34100, Italy. comar@burlo.trieste.it
Abstract
OBJECTIVE: To test the hypothesis that p53 homozygous Arg/Arg genotype at codon 72 is a significant risk factor for the development of HPV induced cervical cancer. STUDY DESIGN: A cross-sectional survey on p53 allelotypes distribution in women with different grade of cervical lesions and with or without HPV infection, in comparison to the distribution on a control group of women cytologically normal and HPV negative. RESULTS: No statistically significant difference in the p53 polymorphism distribution was found in relation to the infection with HPV, the cytological pattern and both conditions. A modest but constant over-representation of Pro-allelotypes was found in all groups in comparison to the control group. CONCLUSION: Searching for p53 polymorphism in a clinical setting does not seem to support secondary prevention procedures, at least for women in this area.
OBJECTIVE: To test the hypothesis that p53 homozygous Arg/Arg genotype at codon 72 is a significant risk factor for the development of HPV induced cervical cancer. STUDY DESIGN: A cross-sectional survey on p53 allelotypes distribution in women with different grade of cervical lesions and with or without HPV infection, in comparison to the distribution on a control group of women cytologically normal and HPV negative. RESULTS: No statistically significant difference in the p53 polymorphism distribution was found in relation to the infection with HPV, the cytological pattern and both conditions. A modest but constant over-representation of Pro-allelotypes was found in all groups in comparison to the control group. CONCLUSION: Searching for p53 polymorphism in a clinical setting does not seem to support secondary prevention procedures, at least for women in this area.
Authors: Daniel Hernández-Sotelo; Rubén García-Aguilar; Yaneth Castro-Coronel; Jonathan J Magaña; Marco Antonio Leyva-Vazquez; Luz del Carmen Alarcón-Romero; Esther López-Bayghen; Berenice Illades-Aguiar Journal: Mol Biol Rep Date: 2013-05-16 Impact factor: 2.316
Authors: Jill Koshiol; Allan Hildesheim; Paula Gonzalez; M Concepcion Bratti; Carolina Porras; Mark Schiffman; Rolando Herrero; Ana C Rodriguez; Sholom Wacholder; Meredith Yeager; Stephen J Chanock; Robert D Burk; Sophia S Wang Journal: Cancer Epidemiol Biomarkers Prev Date: 2009-05 Impact factor: 4.254