| Literature DB >> 15139983 |
D Neau1, M Winnock, T Galpérine, A C Jouvencel, L Castéra, E Legrand, E Tranchant, E Balestre, D Lacoste, J M Ragnaud, M Dupon, M E Lafon, F Dabis.
Abstract
The aim of this study was to describe the frequency and significance of isolated antibodies against the hepatitis B virus (HBV) core antigen (HBc) in 2185 HIV-infected patients of the Aquitaine Cohort. Antibodies against HBc were found in 372 subjects (17%). Patients with isolated anti-HBc antibodies were more frequently coinfected with hepatitis C virus (HCV) (58.2%) than those who were anti-HB surface (HBs) antibody positive (22.9%, P<0.001) and those who were dually reactive anti-HBs/anti-HBc antibody positive (27.3%, P<0.001). These results suggest interactions between HBV and HCV. As observed in patients not infected with HIV, the "anti-HBc-alone" serological profile could reflect essentially late immunity with undetectable anti-HBs antibodies. However, an occult HBV infection cannot be ruled out.Entities:
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Year: 2004 PMID： 15139983 DOI： 10.1111/j.1468-1293.2004.00206.x
Source DB: PubMed Journal: HIV Med ISSN： 1464-2662 Impact factor: 3.180