| Literature DB >> 15139761 |
Florencio Zaragoza1, Henrik Stephensen, Sanne M Knudsen, Lone Pridal, Birgitte S Wulff, Karin Rimvall.
Abstract
With the aim of identifying structurally novel, centrally acting histamine H(3) antagonists, arrays of monoacyldiamines were screened. This led to the discovery of a series of 1-alkyl-4-acylpiperazines which were potent antagonists at the human histamine H(3) receptor. The most potent amides had antagonist potencies in the subnanomolar range.Entities:
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Year: 2004 PMID： 15139761 DOI： 10.1021/jm031028z
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446