Literature DB >> 1513881

Molecular analysis of a gene from Bacteroides fragilis involved in metronidazole resistance in Escherichia coli.

G U Wehnert1, V R Abratt, D R Woods.   

Abstract

The region of Bacteroides fragilis DNA on the recombinant plasmid pMT100 responsible for conferring metronidazole resistance in Escherichia coli strains was characterized. An open reading frame (ORF1) of 195 bp encoded a protein of 64 amino acids with a predicted M(r) of 7.3 kDa. Deletion analysis indicated that ORF1 conferred the metronidazole resistance phenotype and encoded a protein with an apparent M(r) of approximately 8-10 kDa.

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Year:  1992        PMID: 1513881     DOI: 10.1016/0147-619x(92)90027-8

Source DB:  PubMed          Journal:  Plasmid        ISSN: 0147-619X            Impact factor:   3.466


  2 in total

1.  Nucleotide sequence analysis of two 5-nitroimidazole resistance determinants from Bacteroides strains and of a new insertion sequence upstream of the two genes.

Authors:  A Haggoud; G Reysset; H Azeddoug; M Sebald
Journal:  Antimicrob Agents Chemother       Date:  1994-05       Impact factor: 5.191

2.  Overexpression of the rhamnose catabolism regulatory protein, RhaR: a novel mechanism for metronidazole resistance in Bacteroides thetaiotaomicron.

Authors:  Ekta H Patel; Lynthia V Paul; Ana I Casanueva; Sheila Patrick; Valerie R Abratt
Journal:  J Antimicrob Chemother       Date:  2009-06-13       Impact factor: 5.790

  2 in total

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