J Lin1, A N Sattar, T Puckree. 1. Department of Microbiology, University of KwaZulu Natal, Durban, South Africa. jlin@pixie.udw.ac.za
Abstract
OBJECTIVE: To obtain a profile of tuberculosis (TB) cases caused by Mycobacterium tuberculosis in northern KwaZulu Natal (KZN) for 2001. METHOD: The demographic and drug resistance characteristics were determined. A total of 251 smear and culture confirmed cases was obtained and the resistance of three major anti-tuberculosis drugs was tested using the proportion method. RESULTS: The patients were mainly from Ngwelezane (57.8%), Stanger (23.5%) and Manguzi (18.7%); 59.0% were male; 54.2% of the isolates were obtained from new TB patients. The mean age of the TB patients was 29.6 years, with the maximum notification age range at 25-34 years. A high prevalence of drug-resistant and multiresistant TB was observed in this region. At least 55% of previously treated and 19% of new cases from all areas were resistant to at least one of the drugs tested. New patients from Ngwelezane and Manguzi area had a high prevalence of any rifampicin resistance (11.0%) and ethambutol resistance (3.9%), respectively. CONCLUSION: Our results indicate that the TB epidemic in northern KZN, especially in Ngwelezane, is severe. An infrastructure to educate stakeholders about the need to ensure consistency in treatment is needed.
OBJECTIVE: To obtain a profile of tuberculosis (TB) cases caused by Mycobacterium tuberculosis in northern KwaZulu Natal (KZN) for 2001. METHOD: The demographic and drug resistance characteristics were determined. A total of 251 smear and culture confirmed cases was obtained and the resistance of three major anti-tuberculosis drugs was tested using the proportion method. RESULTS: The patients were mainly from Ngwelezane (57.8%), Stanger (23.5%) and Manguzi (18.7%); 59.0% were male; 54.2% of the isolates were obtained from new TB patients. The mean age of the TB patients was 29.6 years, with the maximum notification age range at 25-34 years. A high prevalence of drug-resistant and multiresistant TB was observed in this region. At least 55% of previously treated and 19% of new cases from all areas were resistant to at least one of the drugs tested. New patients from Ngwelezane and Manguzi area had a high prevalence of any rifampicin resistance (11.0%) and ethambutol resistance (3.9%), respectively. CONCLUSION: Our results indicate that the TB epidemic in northern KZN, especially in Ngwelezane, is severe. An infrastructure to educate stakeholders about the need to ensure consistency in treatment is needed.
Authors: Soumitesh Chakravorty; Sandy S Roh; Jennifer Glass; Laura E Smith; Ann Marie Simmons; Kevin Lund; Sergey Lokhov; Xin Liu; Peng Xu; Guolong Zhang; Laura E Via; Qingyu Shen; Xianglin Ruan; Xing Yuan; Hong Zhu Zhu; Ekaterina Viazovkina; Shubhada Shenai; Mazhgan Rowneki; Jong Seok Lee; Clifton E Barry; Qian Gao; David Persing; Robert Kwiatkawoski; Martin Jones; Alexander Gall; David Alland Journal: J Clin Microbiol Date: 2016-12-28 Impact factor: 5.948
Authors: Catherine F Houlihan; Portia C Mutevedzi; Richard J Lessells; Graham S Cooke; Frank C Tanser; Marie-Louise Newell Journal: BMC Infect Dis Date: 2010-02-10 Impact factor: 3.090
Authors: João Perdigão; Hugo Silva; Diana Machado; Rita Macedo; Fernando Maltez; Carla Silva; Luisa Jordao; Isabel Couto; Kim Mallard; Francesc Coll; Grant A Hill-Cawthorne; Ruth McNerney; Arnab Pain; Taane G Clark; Miguel Viveiros; Isabel Portugal Journal: BMC Genomics Date: 2014-11-18 Impact factor: 3.969