Literature DB >> 15136695

Genes influencing Parkinson disease onset: replication of PARK3 and identification of novel loci.

N Pankratz1, S K Uniacke, C A Halter, A Rudolph, C W Shults, P M Conneally, T Foroud, W C Nichols.   

Abstract

A genome screen to identify genes influencing the age at Parkinson disease (PD) onset was completed using 276 families without parkin mutations. Significant evidence of linkage to chromosome 2p near the PARK3 locus (logarithm of odds [lod] = 4.8) was observed. Evidence of linkage was also detected to chromosomes 1q (lod = 3.0) and 8q (lod = 2.6). These data suggest that the genes influencing age at PD onset likely differ from those that contribute to PD susceptibility.

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Year:  2004        PMID： 15136695     DOI： 10.1212/01.wnl.0000123112.51368.10

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  12 in total

Review 1.  Genetics of Parkinson disease.

Authors:  Nathan Pankratz; Tatiana Foroud
Journal:  NeuroRx       Date:  2004-04

2.  Sepiapterin reductase expression is increased in Parkinson's disease brain tissue.

Authors:  Jennifer E Tobin; Jing Cui; Jemma B Wilk; Jeanne C Latourelle; Jason M Laramie; Ann C McKee; Mark Guttman; Samer Karamohamed; Anita L DeStefano; Richard H Myers
Journal:  Brain Res       Date:  2007-01-08       Impact factor: 3.252

3.  Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls.

Authors:  Javier Simón-Sánchez; Andrew B Singleton
Journal:  Hum Mol Genet       Date:  2008-03-25       Impact factor: 6.150

4.  Mutations in DJ-1 are rare in familial Parkinson disease.

Authors:  Nathan Pankratz; Michael W Pauciulo; Veronika E Elsaesser; Diane K Marek; Cheryl A Halter; Joanne Wojcieszek; Alice Rudolph; Clifford W Shults; Tatiana Foroud; William C Nichols
Journal:  Neurosci Lett       Date:  2006-09-25       Impact factor: 3.046

5.  The sepiapterin reductase gene region reveals association in the PARK3 locus: analysis of familial and sporadic Parkinson's disease in European populations.

Authors:  M Sharma; J C Mueller; A Zimprich; P Lichtner; A Hofer; P Leitner; S Maass; D Berg; A Dürr; V Bonifati; G De Michele; B Oostra; A Brice; N W Wood; B Muller-Myhsok; T Gasser
Journal:  J Med Genet       Date:  2006-01-27       Impact factor: 6.318

6.  Mutations in GBA are associated with familial Parkinson disease susceptibility and age at onset.

Authors:  W C Nichols; N Pankratz; D K Marek; M W Pauciulo; V E Elsaesser; C A Halter; A Rudolph; J Wojcieszek; R F Pfeiffer; T Foroud
Journal:  Neurology       Date:  2008-11-05       Impact factor: 9.910

7.  Microarray expression analysis reveals genetic pathways implicated in C621 synphilin-1-mediated toxicity.

Authors:  M Bonin; F P Marx; S Kautzmann; O Riess; R Krüger
Journal:  J Neural Transm (Vienna)       Date:  2008-02-22       Impact factor: 3.575

Review 8.  Genes associated with Parkinson syndrome.

Authors:  Saskia Biskup; Manfred Gerlach; Andreas Kupsch; Heinz Reichmann; Peter Riederer; Peter Vieregge; Ullrich Wüllner; Thomas Gasser
Journal:  J Neurol       Date:  2008-09       Impact factor: 4.849

9.  Genotype and age at Parkinson disease diagnosis.

Authors:  Susan Searles Nielsen; Theo K Bammler; Lisa G Gallagher; Federico M Farin; Wt Longstreth; Gary M Franklin; Phillip D Swanson; Harvey Checkoway
Journal:  Int J Mol Epidemiol Genet       Date:  2013-03-18

10.  Genomewide association study for onset age in Parkinson disease.

Authors:  Jeanne C Latourelle; Nathan Pankratz; Alexandra Dumitriu; Jemma B Wilk; Stefano Goldwurm; Gianni Pezzoli; Claudio B Mariani; Anita L DeStefano; Cheryl Halter; James F Gusella; William C Nichols; Richard H Myers; Tatiana Foroud
Journal:  BMC Med Genet       Date:  2009-09-22       Impact factor: 2.103
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