UNLABELLED: This was a study to evaluate the posterior cingulate sign in differential diagnosis between Alzheimer's and frontotemporal disease. The impending availability of effective treatment for Alzheimer's disease makes this differential diagnosis important. METHODS: Images of 20 patients with clinically confirmed or autopsy-proven (10 patients) Alzheimer's disease and 20 patients with clinically confirmed or autopsy-proven (7 patients) frontotemporal disease were compared with the consolidated images of 20 elderly healthy control subjects. The (99m)Tc-hexamethylpropyleneamine oxime SPECT data on brain blood flow from each patient were compared with the consolidated control image using statistical parametric mapping. RESULTS: Sixteen of 20 patients with Alzheimer's disease showed the posterior cingulate sign in the form of significant blood flow reductions; 1 of 20 patients with frontotemporal disease showed the posterior cingulate sign. That patient's illness has evolved into Alzheimer's disease. The remaining 19 patients were negative for the posterior cingulate sign. CONCLUSION: When present, the posterior cingulate sign indicates the presence of Alzheimer's disease; it is apparently absent in frontotemporal disease, thus serving as a differential diagnostic sign. It was absent in 3 patients with proven tangle-predominant Alzheimer's disease.
UNLABELLED: This was a study to evaluate the posterior cingulate sign in differential diagnosis between Alzheimer's and frontotemporal disease. The impending availability of effective treatment for Alzheimer's disease makes this differential diagnosis important. METHODS: Images of 20 patients with clinically confirmed or autopsy-proven (10 patients) Alzheimer's disease and 20 patients with clinically confirmed or autopsy-proven (7 patients) frontotemporal disease were compared with the consolidated images of 20 elderly healthy control subjects. The (99m)Tc-hexamethylpropyleneamine oxime SPECT data on brain blood flow from each patient were compared with the consolidated control image using statistical parametric mapping. RESULTS: Sixteen of 20 patients with Alzheimer's disease showed the posterior cingulate sign in the form of significant blood flow reductions; 1 of 20 patients with frontotemporal disease showed the posterior cingulate sign. That patient's illness has evolved into Alzheimer's disease. The remaining 19 patients were negative for the posterior cingulate sign. CONCLUSION: When present, the posterior cingulate sign indicates the presence of Alzheimer's disease; it is apparently absent in frontotemporal disease, thus serving as a differential diagnostic sign. It was absent in 3 patients with proven tangle-predominant Alzheimer's disease.
Authors: F Streitparth; G Wieners; A Kämena; R J Schröder; H Stiepani; T Kokocinski; R Röttgen; E Steinhagen-Thiessen; R Lenzen-Grossimlimghaus; N Hidajat Journal: Radiologe Date: 2008-02 Impact factor: 0.635
Authors: Hilary A Archer; Nadja Smailagic; Christeena John; Robin B Holmes; Yemisi Takwoingi; Elizabeth J Coulthard; Sarah Cullum Journal: Cochrane Database Syst Rev Date: 2015-06-23
Authors: Matt Aldag; Regina C Armstrong; Faris Bandak; Patrick S F Bellgowan; Timothy Bentley; Sean Biggerstaff; Katrina Caravelli; Joan Cmarik; Alicia Crowder; Thomas J DeGraba; Travis A Dittmer; Richard G Ellenbogen; Colin Greene; Raj K Gupta; Ramona Hicks; Stuart Hoffman; Robert C Latta; Michael J Leggieri; Donald Marion; Robert Mazzoli; Michael McCrea; John O'Donnell; Mark Packer; James B Petro; Todd E Rasmussen; Wendy Sammons-Jackson; Richard Shoge; Victoria Tepe; Ladd A Tremaine; James Zheng Journal: J Neurotrauma Date: 2017-09 Impact factor: 5.269
Authors: H Matsuda; S Mizumura; T Nagao; T Ota; T Iizuka; K Nemoto; N Takemura; H Arai; A Homma Journal: AJNR Am J Neuroradiol Date: 2007-04 Impact factor: 3.825
Authors: Weiying Dai; Owen T Carmichael; Oscar L Lopez; James T Becker; Lewis H Kuller; H Michael Gach Journal: J Magn Reson Imaging Date: 2008-12 Impact factor: 4.813