Literature DB >> 15136228

e6a2 BCR-ABL transcript in chronic myeloid leukemia: is it associated with aggressive disease?

Simona Colla, Gabriella Sammarelli, Simone Voltolini, Monica Crugnola, Paola Sebastio, Nicola Giuliani.   

Abstract

We describe the fourth case of e6a2 BCR-ABL transcript in a patient with chronic myeloid leukemia (CML), using reverse transcriptase polymerase chain reaction (RT-PCR) and sequencing analysis. The clinical and hematologic features and the aggressive course of disease in our patient and in the others reported in literature lead us to hypothesize that this atypical rearrangement may be associated with a worse prognosis.

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Year:  2004        PMID： 15136228

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


  10 in total

1.  A double Philadelphia chromosome-positive chronic myeloid leukemia patient, co-expressing P210BCR-ABL1 and P195BCR-ABL1 isoforms.

Authors:  Raquel Vinhas; Alexandra Lourenço; Susana Santos; Patrícia Ribeiro; Madalena Silva; Aida Botelho de Sousa; Pedro V Baptista; Alexandra R Fernandes
Journal:  Haematologica       Date:  2018-08-09       Impact factor: 9.941

2.  BCR-ABL1 e6a2 transcript in chronic myeloid leukemia: biological features and molecular monitoring by droplet digital PCR.

Authors:  Antonella Zagaria; Luisa Anelli; Nicoletta Coccaro; Giuseppina Tota; Paola Casieri; Angelo Cellamare; Luciana Impera; Claudia Brunetti; Angela Minervini; Crescenzio Francesco Minervini; Mario Delia; Cosimo Cumbo; Paola Orsini; Giorgina Specchia; Francesco Albano
Journal:  Virchows Arch       Date:  2015-07-07       Impact factor: 4.064

3.  A case of acute myeloid leukemia with e6a2 BCR-ABL fusion transcript acquired after progressing from chronic myelomonocytic leukemia.

Authors:  Jinjuan Yao; Dan Douer; Lu Wang; Maria E Arcila; Khedoudja Nafa; April Chiu
Journal:  Leuk Res Rep       Date:  2017-01-31

4.  Chronic Myeloid Leukemia with an e6a2 BCR-ABL1 Fusion Transcript: Cooperating Mutations at Blast Crisis and Molecular Monitoring.

Authors:  Mireille Crampe; Karl Haslam; Emma Groarke; Eileen Kelleher; Derville O'Shea; Eibhlin Conneally; Stephen E Langabeer
Journal:  Case Rep Hematol       Date:  2017-10-16

5.  Adult acute megakaryoblastic leukemia: rare association with cytopenias of undetermined significance and p210 and p190 BCR-ABL transcripts.

Authors:  Delia Dima; Liana Oprita; Ana-Maria Rosu; Adrian Trifa; Cristina Selicean; Vlad Moisoiu; Ioana Frinc; Mihnea Zdrenghea; Ciprian Tomuleasa
Journal:  Onco Targets Ther       Date:  2017-10-19       Impact factor: 4.147

6.  Philadelphia chromosome positive AML arising from JAK2-positive myelofibrosis.

Authors:  Marte Karen Brattås; Kyrre Lilleeng; Randi Hovland; Ingvild Jenssen Lægreid; Marta Vorland; Friedemann Leh; Øystein Bruserud; Bjørn Tore Gjertsen; Håkon Reikvam
Journal:  Biomark Res       Date:  2018-11-21

7.  Assessment of individual molecular response in chronic myeloid leukemia patients with atypical BCR-ABL1 fusion transcripts: recommendations by the EUTOS cooperative network.

Authors:  Vivien Schäfer; Helen E White; Gareth Gerrard; Susanne Möbius; Susanne Saussele; Georg-Nikolaus Franke; François-X Mahon; Rodica Talmaci; Dolors Colomer; Simona Soverini; Katerina Machova Polakova; Nicholas C P Cross; Andreas Hochhaus; Thomas Ernst
Journal:  J Cancer Res Clin Oncol       Date:  2021-03-07       Impact factor: 4.553

8.  Optimal Response in a Patient With CML Expressing BCR-ABL1 E6A2 Fusion Transcript With Nilotinib Therapy: A Case Report.

Authors:  Livia Manzella; Elena Tirrò; Silvia Rita Vitale; Adriana Puma; Maria Letizia Consoli; Loredana Tambè; Maria Stella Pennisi; Sandra DI Gregorio; Chiara Romano; Cristina Tomarchio; Francesco DI Raimondo; Fabio Stagno
Journal:  In Vivo       Date:  2020 May-Jun       Impact factor: 2.155

Review 9.  Successful treatment with allogeneic stem cell transplantation followed by DLI and TKIs for e6a2 BCR-ABL-positive acute myeloid leukaemia: A case report and literature review.

Authors:  Yasuhiko Harada; Satoshi Nishiwaki; Takumi Sugimoto; Koichi Onodera; Tatsunori Goto; Takahiko Sato; Sonoko Kamoshita; Naomi Kawashima; Aika Seto; Shingo Okuno; Satomi Yamamoto; Toshihiro Iwasaki; Yukiyasu Ozawa; Koichi Miyamura; Yoshiki Akatsuka; Isamu Sugiura
Journal:  Medicine (Baltimore)       Date:  2017-12       Impact factor: 1.817

Review 10.  Prognostic Significance of Transcript-Type BCR - ABL1 in Chronic Myeloid Leukemia.

Authors:  Matteo Molica; Elisabetta Abruzzese; Massimo Breccia
Journal:  Mediterr J Hematol Infect Dis       Date:  2020-09-01       Impact factor: 2.576
  10 in total

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