Literature DB >> 15135922

A role for substance P in arthritis?

J E Keeble1, S D Brain.   

Abstract

Substance P is a neuropeptide that is released from sensory nerves and which has a number of pro-inflammatory effects. In this article, we review the evidence for a role of substance P in arthritis, both in experimental animal models and rheumatoid arthritis patients. Substance P expression is altered in the joint and dorsal horn of arthritic animals, exogenous substance P and neurokinin 1 (NK(1)) receptor antagonists modulate responses in the joint, and there is some evidence for a role of substance P in human joint disease. However, the therapeutic potential of NK(1) receptor antagonists in the treatment of rheumatoid arthritis remains controversial.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 15135922     DOI： 10.1016/j.neulet.2003.12.020

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  22 in total

1.  Increased neuronal expression of neurokinin-1 receptor and stimulus-evoked internalization of the receptor in the rostral ventromedial medulla of the rat after peripheral inflammatory injury.

Authors:  Marta V Hamity; Roxanne Y Walder; Donna L Hammond
Journal:  J Comp Neurol       Date:  2014-09-01       Impact factor: 3.215

Review 2.  TRPV1 and SP: key elements for sepsis outcome?

Authors:  Jennifer Victoria Bodkin; Elizabeth Soares Fernandes
Journal:  Br J Pharmacol       Date:  2013-12       Impact factor: 8.739

3.  Ablating spinal NK1-bearing neurons eliminates the development of pain and reduces spinal neuronal hyperexcitability and inflammation from mechanical joint injury in the rat.

Authors:  Christine L Weisshaar; Beth A Winkelstein
Journal:  J Pain       Date:  2014-01-02       Impact factor: 5.820

4.  Suppression of Peripheral Pain by Blockade of Voltage-Gated Calcium 2.2 Channels in Nociceptors Induces RANKL and Impairs Recovery From Inflammatory Arthritis in a Mouse Model.

Authors:  Uta Baddack; Silke Frahm; Beatriz Antolin-Fontes; Jenny Grobe; Martin Lipp; Gerd Müller; Ines Ibañez-Tallon
Journal:  Arthritis Rheumatol       Date:  2015-06       Impact factor: 10.995

5.  Chemical parcellation of the anterior thalamic nuclei in the human brain.

Authors:  R Alelú-Paz; J M Giménez-Amaya
Journal:  J Neural Transm (Vienna)       Date:  2007-02-19       Impact factor: 3.575

6.  A novel activity for substance P: stimulation of peroxisome proliferator-activated receptor-gamma protein expression in human monocytes and macrophages.

Authors:  A Amoruso; C Bardelli; G Gunella; F Ribichini; S Brunelleschi
Journal:  Br J Pharmacol       Date:  2008-02-18       Impact factor: 8.739

7.  Substance P upregulates LTB4 in rat adherent macrophages from granuloma induced by KMnO4.

Authors:  M L Castellani; P Conti; M Felaco; J Vecchiet; C Ciampoli; G Cerulli; P Boscolo; T C Theoharides
Journal:  Neurotox Res       Date:  2009-02-18       Impact factor: 3.911

8.  Effects of neurokinin-1 receptor agonism and antagonism in the rostral ventromedial medulla of rats with acute or persistent inflammatory nociception.

Authors:  M V Hamity; S R White; D L Hammond
Journal:  Neuroscience       Date:  2009-11-03       Impact factor: 3.590

9.  Role of capsaicin-sensitive nerves and tachykinins in mast cell tryptase-induced inflammation of murine knees.

Authors:  Éva Borbély; Katalin Sándor; Adrienn Markovics; Ágnes Kemény; Erika Pintér; János Szolcsányi; John P Quinn; Jason J McDougall; Zsuzsanna Helyes
Journal:  Inflamm Res       Date:  2016-06-01       Impact factor: 4.575

10.  Pain from intra-articular NGF or joint injury in the rat requires contributions from peptidergic joint afferents.

Authors:  Jeffrey V Kras; Christine L Weisshaar; Parul S Pall; Beth A Winkelstein
Journal:  Neurosci Lett       Date:  2015-08-01       Impact factor: 3.046
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.