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Literature DB >> 15130577

Guardian at the gate: preventing unspliced pre-mRNA export.

Abstract

The production of a mature mRNA requires the assembly and cooperation of numerous complexes before nuclear export. The deleterious effects of intron-containing pre-mRNA leakage into the cytoplasm necessitate mechanisms to prevent premature export of partially processed or unprocessed messages. A new study demonstrates that the Saccharomyces cerevisiae protein Mlp1 specifically retains intron-containing pre-mRNAs in the nucleus.

Entities: Gene Species

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Year: 2004 PMID： 15130577 DOI： 10.1016/j.tcb.2004.03.007

Source DB: PubMed Journal: Trends Cell Biol ISSN： 0962-8924 Impact factor: 20.808

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Cited

5 in total

1. Following temperature stress, export of heat shock mRNA occurs efficiently in cells with mutations in genes normally important for mRNA export.

Authors: Christiane Rollenhagen; Christine A Hodge; Charles N Cole
Journal: Eukaryot Cell Date: 2007-01-26

Guardian at the gate: preventing unspliced pre-mRNA export.

1. Following temperature stress, export of heat shock mRNA occurs efficiently in cells with mutations in genes normally important for mRNA export.

2. RNA-RNA interactions and pre-mRNA mislocalization as drivers of group II intron loss from nuclear genomes.

3. Systematic deletion and mitotic localization of the nuclear pore complex proteins of Aspergillus nidulans.

4. STABILIZED1 as a heat stress-specific splicing factor in Arabidopsis thaliana.

5. Karyopherin binding interactions and nuclear import mechanism of nuclear pore complex protein Tpr.