| Literature DB >> 15130503 |
Edward M Bertram1, Wojciech Dawicki, Tania H Watts.
Abstract
Members of both the CD28 and TNFR families can have costimulatory roles in T cell activation. Gene targeted mice as well as in vivo blocking experiments have established distinct roles for CD28/B7; ICOS/ICOSL; CD27/CD70; 4-1BB/4-1BBL and OX40/OX40L during viral infection. Many issues remain to be addressed, including the timing and location of the interactions, the possibility of partial redundancy between related family members and the molecular basis for the specific phenotypes observed in the different gene targeted mice.Entities:
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Year: 2004 PMID: 15130503 DOI: 10.1016/j.smim.2004.02.006
Source DB: PubMed Journal: Semin Immunol ISSN: 1044-5323 Impact factor: 11.130