| Literature DB >> 15129996 |
Marinês J e Souza1, Celso F Bittencourt, Paulo da S e Souza Filho.
Abstract
A simple, sensitive and specific agar diffusion bioassay for the antibacterial enrofloxacin was developed. Using a strain of Staphylococcus aureus ATCC 6538P as the test organism, enrofloxacin at concentrations ranging from 3.2 to 12.8 microg ml(-1) could be measured in injection. A prospective validation of the method showed that method was linear (r = 0.99998), precise (R.S.D. = 0.27) and accurate (it measured the added quantities). The method shows results that confirm its precision, not differing significantly the other method described in the literature. We conclude that microbiological assay is satisfactory for quantitation of in vitro antibacterial activity of enrofloxacin.Entities:
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Year: 2004 PMID： 15129996 DOI： 10.1016/j.ijpharm.2003.11.012
Source DB: PubMed Journal: Int J Pharm ISSN： 0378-5173 Impact factor: 5.875