| Literature DB >> 15129995 |
Anant Paradkar1, Anshuman A Ambike, Bhimrao K Jadhav, K R Mahadik.
Abstract
Curcumin, a naturally occurring highly lipophilic molecule has wide range of pharmacological activities. However, its limited aqueous solubility and degradation at alkaline pH restricts its bioavailability. Solid dispersions of curcumin in different ratios with PVP were prepared by spray drying. Physical characterization by SEM, IR, DSC, and XRPD studies, in comparison with corresponding physical mixtures revealed the changes in solid state during the formation of dispersion and justified the formation of high-energy amorphous phase. Dissolution studies of curcumin and its physical mixtures in 0.1 N HCl showed negligible release even after 90 min. Whereas, solid dispersions showed complete dissolution within 30 min. This may aid in improving bioavailability and dose reduction of the drug.Entities:
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Year: 2004 PMID： 15129995 DOI： 10.1016/j.ijpharm.2003.11.014
Source DB: PubMed Journal: Int J Pharm ISSN： 0378-5173 Impact factor: 5.875