OBJECTIVES: To examine the association between intrauterine growth restriction and neurodevelopmental outcome among full-term small-for-gestational-age (SGAT) infants at 8 months and 4 years of age. STUDY DESIGN: Growth parameters at birth and test scores on measures of neurodevelopmental function for 3922 children born SGAT were compared with those of 29,369 children born appropriately grown-for-gestational-age term from similar economic backgrounds. Additional within-SGAT/economic group comparisons were made for 1684 SGAT infants with symmetric undergrowth at birth and 2034 SGAT infants with asymmetric undergrowth at birth. RESULTS: Regardless of socioeconomic background, infants born SGAT were found to be at significantly increased risk for neurodevelopmental difficulties at 8 months and at 4 years of age. Few within SGAT/socioeconomic group differences in neurodevelopmental outcome appeared to be associated with specific pattern of growth restriction at birth. CONCLUSIONS: The present findings provide further evidence of the individual and public health impact of SGAT birth.
OBJECTIVES: To examine the association between intrauterine growth restriction and neurodevelopmental outcome among full-term small-for-gestational-age (SGAT) infants at 8 months and 4 years of age. STUDY DESIGN: Growth parameters at birth and test scores on measures of neurodevelopmental function for 3922 childrenborn SGAT were compared with those of 29,369 children born appropriately grown-for-gestational-age term from similar economic backgrounds. Additional within-SGAT/economic group comparisons were made for 1684 SGAT infants with symmetric undergrowth at birth and 2034 SGAT infants with asymmetric undergrowth at birth. RESULTS: Regardless of socioeconomic background, infantsborn SGAT were found to be at significantly increased risk for neurodevelopmental difficulties at 8 months and at 4 years of age. Few within SGAT/socioeconomic group differences in neurodevelopmental outcome appeared to be associated with specific pattern of growth restriction at birth. CONCLUSIONS: The present findings provide further evidence of the individual and public health impact of SGAT birth.
Authors: Jorge Pereyra Pena; Takuji Tomimatsu; Douglas P Hatran; Lisa L McGill; Lawrence D Longo Journal: J Physiol Date: 2006-10-26 Impact factor: 5.182
Authors: Ronald M Adkins; Julia Krushkal; Everett F Magann; Chad K Klauser; John C Morrison; Risa Ramsey; Grant Somes Journal: Int J Pediatr Obes Date: 2010-04