Literature DB >> 15129158

Delayed neurotrophin treatment supports auditory neuron survival in deaf guinea pigs.

Lisa N Gillespie1, Graeme M Clark, Phillip L Marzella.   

Abstract

As key factors in the development and maintenance of the auditory system, neurotrophins can prevent auditory neuron degeneration when applied within three to five days of deafening. We tested each of the neurotrophins BDNF, NT-3, NT-4/5 and NGF for their ability to support auditory neuron survival following a two-week period of deafness in guinea pigs, when approximately 15% auditory neuron degeneration has already occurred. Although delayed, the treatment with each neurotrophin prevented further degeneration with similar efficacy. Copyright 2004 Lippincott Williams and Wilkins

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Year:  2004        PMID： 15129158     DOI： 10.1097/00001756-200405190-00008

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  27 in total

1.  Auditory hair cell explant co-cultures promote the differentiation of stem cells into bipolar neurons.

Authors:  B Coleman; J B Fallon; L N Pettingill; M G de Silva; R K Shepherd
Journal:  Exp Cell Res       Date:  2006-10-24       Impact factor: 3.905

2.  Exogenous BDNF rescues rat spiral ganglion neurons in vivo.

Authors:  Sarah L McGuinness; Robert K Shepherd
Journal:  Otol Neurotol       Date:  2005-09       Impact factor: 2.311

3.  Impact of sound exposure and aging on brain-derived neurotrophic factor and tyrosine kinase B receptors levels in dorsal cochlear nucleus 80 days following sound exposure.

Authors:  H Wang; T J Brozoski; L Ling; L F Hughes; D M Caspary
Journal:  Neuroscience       Date:  2010-10-27       Impact factor: 3.590

Review 4.  Mechanisms of noise-induced hearing loss indicate multiple methods of prevention.

Authors:  Colleen G Le Prell; Daisuke Yamashita; Shujiro B Minami; Tatsuya Yamasoba; Josef M Miller
Journal:  Hear Res       Date:  2006-12-04       Impact factor: 3.208

Review 5.  Neurotrophic factors and neural prostheses: potential clinical applications based upon findings in the auditory system.

Authors:  Lisa N Pettingill; Rachael T Richardson; Andrew K Wise; Stephen J O'Leary; Robert K Shepherd
Journal:  IEEE Trans Biomed Eng       Date:  2007-06       Impact factor: 4.538

6.  Post-treatment effects of local GDNF administration to the inner ears of deafened guinea pigs.

Authors:  Anette Fransson; Jun Maruyama; Josef M Miller; Mats Ulfendahl
Journal:  J Neurotrauma       Date:  2010-09       Impact factor: 5.269

7.  Spiral ganglion neuron survival and function in the deafened cochlea following chronic neurotrophic treatment.

Authors:  Thomas G Landry; Andrew K Wise; James B Fallon; Robert K Shepherd
Journal:  Hear Res       Date:  2011-07-06       Impact factor: 3.208

8.  Chronic depolarization enhances the trophic effects of brain-derived neurotrophic factor in rescuing auditory neurons following a sensorineural hearing loss.

Authors:  Robert K Shepherd; Anne Coco; Stephanie B Epp; Jeremy M Crook
Journal:  J Comp Neurol       Date:  2005-05-30       Impact factor: 3.215

Review 9.  Challenges for stem cells to functionally repair the damaged auditory nerve.

Authors:  Karina Needham; Ricki L Minter; Robert K Shepherd; Bryony A Nayagam
Journal:  Expert Opin Biol Ther       Date:  2012-10-25       Impact factor: 4.388

10.  Enhanced survival of spiral ganglion cells after cessation of treatment with brain-derived neurotrophic factor in deafened guinea pigs.

Authors:  Martijn J H Agterberg; Huib Versnel; Lotte M van Dijk; John C M J de Groot; Sjaak F L Klis
Journal:  J Assoc Res Otolaryngol       Date:  2009-04-14
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