| Literature DB >> 1512860 |
A Ebner1, C Jiang, S Lindström.
Abstract
The working mechanism of intravesical electrical stimulation (IVES) was evaluated in alpha-chloralose anaesthetized cats and rats. IVES involved a direct activation of bladder mechanoreceptor afferents of the A delta type and as a consequence a central reflex activation of the detrusor. The detrusor response was abolished by bilateral transection of the S1-S3 dorsal roots and by intravesical instillation of lidocaine. The optimal stimulation frequency was 20 Hz. The results offer a theoretical rationale for the use of IVES as treatment of weak detrusor contractility in man.Entities:
Mesh:
Year: 1992 PMID: 1512860 DOI: 10.1016/s0022-5347(17)36778-2
Source DB: PubMed Journal: J Urol ISSN: 0022-5347 Impact factor: 7.450