Barrett's esophagus: best of Digestive Disease Week 2003.

The definition of Barrett's esophagus is conceptually simple. It is the replacement of the normal squamous mucosa by specialized intestinal metaplasia within the esophagus. Barrett's esophagus would only be a clinical curiosity if not for its predisposition toward neoplastic change. In spite of all the knowledge and data gathered thus far on Barrett's, much remains unknown. Why do some patients develop Barrett's while others do not? Why do some with Barrett's advance to adenocarcinoma? Once Barrett's develops, what is the optimal prevention strategy for adenocarcinoma? These clinical unknowns touch only the tip of the iceberg and have made Barrett's esophagus a subject of intense research. This review offers some of the highlights from Digestive Disease Week 2003, comprised of posters of distinction and oral presentations.