Literature DB >> 15128253

Solid-phase synthesis of constrained terminal and internal lactam peptidomimetics.

William L Scott1, Jordi Alsina, Joseph H Kennedy, Martin J O'Donnell.   

Abstract

Lactams are key components of many peptidomimetic structures. Five- and six-membered lactam peptidomimetics with hydrogen or amino acid side chains at the alpha-position can be constructed from peptide precursors during a solid-phase synthesis. There is no significant racemization of remote stereocenters during synthesis.

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Year:  2004        PMID： 15128253     DOI： 10.1021/ol049547z

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  7 in total

1.  Intramolecular anodic olefin coupling reactions: use of the reaction rate to control substrate/product selectivity.

Authors:  Hai-Chao Xu; Kevin D Moeller
Journal:  Angew Chem Int Ed Engl       Date:  2010-10-18       Impact factor: 15.336

2.  Intramolecular hydroamination of dithioketene acetals: an easy route to cyclic amino acid derivatives.

Authors:  Hai-Chao Xu; Kevin D Moeller
Journal:  Org Lett       Date:  2010-10-14       Impact factor: 6.005

3.  Intramolecular anodic olefin coupling reactions and the synthesis of cyclic amines.

Authors:  Hai-Chao Xu; Kevin D Moeller
Journal:  J Am Chem Soc       Date:  2010-03-03       Impact factor: 15.419

4.  Solid-phase synthesis of tetrahydropyridazinedione-constrained peptides.

Authors:  Chang Won Kang; Sujeewa Ranatunga; Matthew P Sarnowski; Juan R Del Valle
Journal:  Org Lett       Date:  2014-10-08       Impact factor: 6.005

5.  Distributed Drug Discovery, Part 2: global rehearsal of alkylating agents for the synthesis of resin-bound unnatural amino acids and virtual D(3) catalog construction.

Authors:  William L Scott; Jordi Alsina; Christopher O Audu; Evgenii Babaev; Linda Cook; Jeffery L Dage; Lawrence A Goodwin; Jacek G Martynow; Dariusz Matosiuk; Miriam Royo; Judith G Smith; Andrew T Strong; Kirk Wickizer; Eric M Woerly; Ziniu Zhou; Martin J O'Donnell
Journal:  J Comb Chem       Date:  2009 Jan-Feb

6.  Distributed Drug Discovery, Part 1: linking academia and combinatorial chemistry to find drug leads for developing world diseases.

Authors:  William L Scott; Martin J O'Donnell
Journal:  J Comb Chem       Date:  2009 Jan-Feb

7.  Distributed Drug Discovery, Part 3: using D(3) methodology to synthesize analogs of an anti-melanoma compound.

Authors:  William L Scott; Christopher O Audu; Jeffery L Dage; Lawrence A Goodwin; Jacek G Martynow; Laura K Platt; Judith G Smith; Andrew T Strong; Kirk Wickizer; Eric M Woerly; Martin J O'Donnell
Journal:  J Comb Chem       Date:  2009 Jan-Feb
  7 in total

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