Literature DB >> 1512819

Periodicity of presentations of drugs of abuse and overdose in an emergency department.

R C Raymond1, M Warren, R W Morris, J B Leikin.   

Abstract

In order to determine whether temporal factors impact on drugs of abuse and overdose presentations to an urban emergency department, we studied the records of 630 consecutive drug overdose presentations over a period from October 1987 to March 1990. Particular note was made of the time of day of presentation along with the nature of the drug(s) ingested. A significant curve (p less than 0.0005) was obtained for a 24 h period with a peak time of presentation being 6:32 pm (95% confidence interval of 1 h 54 min). Significant periodic rhythms were noted for cocaine, opiates, alcohol, analgesics, marijuana, and benzodiazepines. A 4.8 h periodic rhythm was demonstrated for cocaine, marijuana and alcohol-in-combination. We conclude that the emergency department should be most prepared to treat the drug overdose patient in the early evening and emergency department staffing should reflect this peak in demand.

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Year:  1992        PMID: 1512819     DOI: 10.3109/15563659209021561

Source DB:  PubMed          Journal:  J Toxicol Clin Toxicol        ISSN: 0731-3810


  13 in total

1.  Period 2 gene deletion abolishes beta-endorphin neuronal response to ethanol.

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2.  Photoperiodic suppression of drug reinstatement.

Authors:  B A Sorg; G Stark; A Sergeeva; H T Jansen
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3.  Learned motivation drives circadian physiology in the absence of the master circadian clock.

Authors:  Oliver Rawashdeh; Shannon J Clough; Randall L Hudson; Margarita L Dubocovich
Journal:  FASEB J       Date:  2016-10-12       Impact factor: 5.191

4.  Free-running rhythms of cocaine self-administration in rats held under constant lighting conditions.

Authors:  Caroline E Bass; Heiko T Jansen; David C S Roberts
Journal:  Chronobiol Int       Date:  2010-05       Impact factor: 2.877

5.  Acute morphine affects the rat circadian clock via rhythms of phosphorylated ERK1/2 and GSK3β kinases and Per1 expression in the rat suprachiasmatic nucleus.

Authors:  Dominika Pačesová; Barbora Volfová; Kateřina Červená; Lucie Hejnová; Jiří Novotný; Zdeňka Bendová
Journal:  Br J Pharmacol       Date:  2015-05-11       Impact factor: 8.739

6.  Fentanyl, but not haloperidol, entrains persisting circadian activity episodes when administered at 24- and 31-h intervals.

Authors:  Andrea G Gillman; Joseph K Leffel; Ann E K Kosobud; William Timberlake
Journal:  Behav Brain Res       Date:  2009-07-10       Impact factor: 3.332

7.  The Brain's Reward System in Health and Disease.

Authors:  Robert G Lewis; Ermanno Florio; Daniela Punzo; Emiliana Borrelli
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

8.  Genetic deletion of the MT1 or MT2 melatonin receptors abrogates methamphetamine-induced reward in C3H/HeN mice.

Authors:  Shannon J Clough; Anthony J Hutchinson; Randall L Hudson; Margarita L Dubocovich
Journal:  Physiol Behav       Date:  2014-05-09

Review 9.  A role for the circadian genes in drug addiction.

Authors:  Edgardo Falcón; Colleen A McClung
Journal:  Neuropharmacology       Date:  2008-07-03       Impact factor: 5.250

10.  A new (and different) circadian pacemaker.

Authors:  Jennifer A Mohawk; Michael Menaker
Journal:  Cell Cycle       Date:  2009-09-30       Impact factor: 4.534

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