BACKGROUND: The recurrent aphthous stomatitis (RAS) is a common disease with unknown etiology. Helicobacter pylori has been shown to be the causative factor in peptic ulcers. Considering the similarities of histologic features between gastric and oral ulceration, we studied the possible involvement of H. pylori in the development of RAS. METHODS: A total of 105 children and adolescents were investigated--53 patients with RAS (case group) and 52 patients without lesions (control group). Specimens obtained by swabbing RAS lesions, intact oral mucosa, and dental plaque were submitted to a polymerase chain reaction (PCR)-based assay. RESULTS: Helicobacter pylori was present in six patients of the case group (11.3%) and in three of the control group (5.8%). When the site of infection was studied, 9.4% of the RAS lesions were PCR positives. In the case group and control group, 5.7 and 1.9% of the specimens from dental plaque, respectively, and 5.7 and 3.8% of the specimens from the intact oral mucosa, respectively, were PCR positives. CONCLUSION: There was no association between RAS lesions and infection of the oral cavity by H. pylori in children and adolescents (P = 0.254).
BACKGROUND: The recurrent aphthous stomatitis (RAS) is a common disease with unknown etiology. Helicobacter pylori has been shown to be the causative factor in peptic ulcers. Considering the similarities of histologic features between gastric and oral ulceration, we studied the possible involvement of H. pylori in the development of RAS. METHODS: A total of 105 children and adolescents were investigated--53 patients with RAS (case group) and 52 patients without lesions (control group). Specimens obtained by swabbing RAS lesions, intact oral mucosa, and dental plaque were submitted to a polymerase chain reaction (PCR)-based assay. RESULTS:Helicobacter pylori was present in six patients of the case group (11.3%) and in three of the control group (5.8%). When the site of infection was studied, 9.4% of the RAS lesions were PCR positives. In the case group and control group, 5.7 and 1.9% of the specimens from dental plaque, respectively, and 5.7 and 3.8% of the specimens from the intact oral mucosa, respectively, were PCR positives. CONCLUSION: There was no association between RAS lesions and infection of the oral cavity by H. pylori in children and adolescents (P = 0.254).
Authors: Ag Gravina; A Federico; E Ruocco; A Lo Schiavo; M Masarone; C Tuccillo; F Peccerillo; A Miranda; L Romano; C de Sio; I de Sio; M Persico; V Ruocco; G Riegler; C Loguercio; M Romano Journal: United European Gastroenterol J Date: 2015-02 Impact factor: 4.623
Authors: Marcella Pedullà; Vincenzo Fierro; Ester Del Tufo; Rossella Alfano; Maria Triassi; Laura Perrone Journal: United European Gastroenterol J Date: 2014-08 Impact factor: 4.623
Authors: Arwa Al Sayed; Pradeep S Anand; Kavitha P Kamath; Shankargouda Patil; R S Preethanath; Sukumaran Anil Journal: ISRN Gastroenterol Date: 2014-02-20