Literature DB >> 15127450

Isolation and characterization of pre-rapamycin, the first macrocyclic intermediate in the biosynthesis of the immunosuppressant rapamycin by S. hygroscopicus.

Matthew A Gregory1, Sabine Gaisser, Rachel E Lill, Hui Hong, Rose M Sheridan, Barrie Wilkinson, Hrvoje Petkovic, Alison J Weston, Isabelle Carletti, Huai-Lo Lee, James Staunton, Peter F Leadlay.   

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Year:  2004        PMID： 15127450     DOI： 10.1002/anie.200453764

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  10 in total

1.  Production of novel rapamycin analogs by precursor-directed biosynthesis.

Authors:  Frank V Ritacco; Edmund I Graziani; Mia Y Summers; T Mark Zabriskie; Ker Yu; Valerie S Bernan; Guy T Carter; Michael Greenstein
Journal:  Appl Environ Microbiol       Date:  2005-04       Impact factor: 4.792

2.  Characterization of negative regulatory genes for the biosynthesis of rapamycin in Streptomyces rapamycinicus and its application for improved production.

Authors:  Young Ji Yoo; Jae-Yeon Hwang; Hea-Luyung Shin; Heqing Cui; Jinwon Lee; Yeo Joon Yoon
Journal:  J Ind Microbiol Biotechnol       Date:  2014-11-26       Impact factor: 3.346

3.  Insights into the metabolic mechanism of rapamycin overproduction in the shikimate-resistant Streptomyces hygroscopicus strain UV-II using comparative metabolomics.

Authors:  Huiyan Geng; Huanhuan Liu; Jiao Liu; Cheng Wang; Jianping Wen
Journal:  World J Microbiol Biotechnol       Date:  2017-05-02       Impact factor: 3.312

4.  Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate.

Authors:  Jennifer N Andexer; Steven G Kendrew; Mohammad Nur-e-Alam; Orestis Lazos; Teresa A Foster; Anna-Sophie Zimmermann; Tony D Warneck; Dipen Suthar; Nigel J Coates; Frank E Koehn; Jerauld S Skotnicki; Guy T Carter; Matthew A Gregory; Christine J Martin; Steven J Moss; Peter F Leadlay; Barrie Wilkinson
Journal:  Proc Natl Acad Sci U S A       Date:  2011-03-07       Impact factor: 11.205

5.  Crossregulation of rapamycin and elaiophylin biosynthesis by RapH in Streptomyces rapamycinicus.

Authors:  Wenyan He; Wenfang Wang; Jiaxiang Ma; Guosong Zheng; Andrei A Zimin; Weihong Jiang; Jinzhong Tian; Yinhua Lu
Journal:  Appl Microbiol Biotechnol       Date:  2022-02-26       Impact factor: 4.813

Review 6.  Rapamycin golden jubilee and still the miraculous drug: a potent immunosuppressant, antitumor, rejuvenative agent, and potential contributor in COVID-19 treatment.

Authors:  Mohamed A Mohamed; Waill A Elkhateeb; Ghoson M Daba
Journal:  Bioresour Bioprocess       Date:  2022-06-13

Review 7.  An overview of rapamycin: from discovery to future perspectives.

Authors:  Young Ji Yoo; Hanseong Kim; Sung Ryeol Park; Yeo Joon Yoon
Journal:  J Ind Microbiol Biotechnol       Date:  2016-09-09       Impact factor: 3.346

8.  Roles of rapH and rapG in positive regulation of rapamycin biosynthesis in Streptomyces hygroscopicus.

Authors:  Enej Kuscer; Nigel Coates; Iain Challis; Matt Gregory; Barrie Wilkinson; Rose Sheridan; Hrvoje Petković
Journal:  J Bacteriol       Date:  2007-04-27       Impact factor: 3.490

9.  An Efficient Method To Generate Gene Deletion Mutants of the Rapamycin-Producing Bacterium Streptomyces iranensis HM 35.

Authors:  Tina Netzker; Volker Schroeckh; Matthew A Gregory; Michal Flak; Mario K C Krespach; Peter F Leadlay; Axel A Brakhage
Journal:  Appl Environ Microbiol       Date:  2016-05-31       Impact factor: 4.792

Review 10.  Streptomyces: host for refactoring of diverse bioactive secondary metabolites.

Authors:  Vivek Sharma; Randhir Kaur; Richa Salwan
Journal:  3 Biotech       Date:  2021-06-16       Impact factor: 2.893
  10 in total

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