Michael G Oefelein1, Martin I Resnick. 1. Department of Urology, Case Western University School of Medicine, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA. michael.oefelein@uhhs.com
Abstract
PURPOSE: We identified time to the development of hormone refractory prostate cancer (HRPC) and survival in men with advanced prostate cancer and examined any association with cigarette smoking history. MATERIALS AND METHODS: The study design was retrospective. A complete tobacco history was obtained in 222 patients with advanced prostate cancer. HRPC was diagnosed in 133 of these 222 patients and death occurred in 77. Standard statistical methods and software were used to analyze these data. RESULTS: Median time to HRPC was 11, 23 and 35 months in patients with a current, former or never smoked tobacco history (p = 0.00001). Median overall survival time on androgen ablative therapy was 38, 47 and 60 months in patients with a current, former or never smoked tobacco history, respectively (p = 0.00001). CONCLUSIONS: Tobacco use independently correlates with time to HRPC and survival in a dose dependent manner in patients with advanced prostate cancer on androgen deprivation therapy.
PURPOSE: We identified time to the development of hormone refractory prostate cancer (HRPC) and survival in men with advanced prostate cancer and examined any association with cigarette smoking history. MATERIALS AND METHODS: The study design was retrospective. A complete tobacco history was obtained in 222 patients with advanced prostate cancer. HRPC was diagnosed in 133 of these 222 patients and death occurred in 77. Standard statistical methods and software were used to analyze these data. RESULTS: Median time to HRPC was 11, 23 and 35 months in patients with a current, former or never smoked tobacco history (p = 0.00001). Median overall survival time on androgen ablative therapy was 38, 47 and 60 months in patients with a current, former or never smoked tobacco history, respectively (p = 0.00001). CONCLUSIONS:Tobacco use independently correlates with time to HRPC and survival in a dose dependent manner in patients with advanced prostate cancer on androgen deprivation therapy.
Authors: Corinne E Joshu; Alison M Mondul; Cari L Meinhold; Elizabeth B Humphreys; Misop Han; Patrick C Walsh; Elizabeth A Platz Journal: J Natl Cancer Inst Date: 2011-04-15 Impact factor: 13.506
Authors: Daniel M Moreira; William J Aronson; Martha K Terris; Christopher J Kane; Christopher L Amling; Matthew R Cooperberg; Paolo Boffetta; Stephen J Freedland Journal: Cancer Date: 2013-10-11 Impact factor: 6.860
Authors: Eric C Kauffman; Brian D Robinson; Martin J Downes; Leagh G Powell; Ming Ming Lee; Douglas S Scherr; Lorraine J Gudas; Nigel P Mongan Journal: Mol Carcinog Date: 2011-03-11 Impact factor: 4.784
Authors: June M Chan; Stacey A Kenfield; Rebecca E Graff; Crystal S Langlais; Erin L Van Blarigan; Claire H Pernar; Meir J Stampfer; Edward L Giovannucci; Lorelei A Mucci Journal: Br J Cancer Date: 2022-08-26 Impact factor: 9.075
Authors: M May; C Gilfrich; P Spachmann; O Maurer; M K Dombrowski; H M Fritsche; M Wöhr; S Brookman-May; T Karl; M Schostak; M Burger; S Lebentrau Journal: Urologe A Date: 2016-08 Impact factor: 0.639