PURPOSE AND METHODS: Breakdown rates of very low density lipoprotein triacylglycerols (VLDL-TAG) were quantified before (3 h), during (45 min), and after (3 h) moderate physical exercise at 40% VO2 max in young sedentary subjects (four male and four female, age 29.8 +/-1.6 yr, BMI 24.1 +/- 0.9 kg x m, VO2max 37.0 +/- 1.7 mL x kg x min), using boluses of H5-glycerol (100 mu mol x kg) and H2-palmitate (6.6 mu mol x kg). The catabolic rates of VLDL-TAG were calculated from the decay in the isotopic enrichment using a single-pool model. The results were compared with those obtained during 6 h of rest in five of the same volunteers. RESULTS: VLDL-TAG concentration remained constant throughout the study with exercise (P = NS). The fractional catabolic rate was nearly doubled from rest to exercise (P < 0.05 vs rest) and increased to an even greater extent during the early phase of recovery (P < 0.001 vs rest). During the late recovery phase, the value returned to the preexercise value (P = NS vs rest). The values for the absolute catabolic rate (kabs) followed the same trend. CONCLUSION: VLDL-TAG turnover was increased during exercise and during the early phase of recovery.
PURPOSE AND METHODS: Breakdown rates of very low density lipoprotein triacylglycerols (VLDL-TAG) were quantified before (3 h), during (45 min), and after (3 h) moderate physical exercise at 40% VO2 max in young sedentary subjects (four male and four female, age 29.8 +/-1.6 yr, BMI 24.1 +/- 0.9 kg x m, VO2max 37.0 +/- 1.7 mL x kg x min), using boluses of H5-glycerol (100 mu mol x kg) and H2-palmitate (6.6 mu mol x kg). The catabolic rates of VLDL-TAG were calculated from the decay in the isotopic enrichment using a single-pool model. The results were compared with those obtained during 6 h of rest in five of the same volunteers. RESULTS: VLDL-TAG concentration remained constant throughout the study with exercise (P = NS). The fractional catabolic rate was nearly doubled from rest to exercise (P < 0.05 vs rest) and increased to an even greater extent during the early phase of recovery (P < 0.001 vs rest). During the late recovery phase, the value returned to the preexercise value (P = NS vs rest). The values for the absolute catabolic rate (kabs) followed the same trend. CONCLUSION: VLDL-TAG turnover was increased during exercise and during the early phase of recovery.
Authors: Demidmaa Tuvdendorj; Xiao-jun Zhang; David L Chinkes; Lijian Wang; Zhanpin Wu; Noe A Rodriguez; David N Herndon; Robert R Wolfe Journal: Metabolism Date: 2015-01-08 Impact factor: 8.694
Authors: Esben Sondergaard; Iben Rahbek; Lars P Sørensen; Jens S Christiansen; Lars C Gormsen; Michael D Jensen; Søren Nielsen Journal: Am J Physiol Endocrinol Metab Date: 2011-03-08 Impact factor: 4.310
Authors: P Motiani; J Teuho; T Saari; K A Virtanen; S M Honkala; R J Middelbeek; L J Goodyear; O Eskola; J Andersson; E Löyttyniemi; J C Hannukainen; P Nuutila Journal: Obes Sci Pract Date: 2019-04-24