Literature DB >> 15125968

Synthesis and DNA damaging ability of enediyne model compounds possessing photo-triggering devices.

Ichiro Suzuki1, Shinsaku Uno, Yuko Tsuchiya, Akira Shigenaga, Hisao Nemoto, Masayuki Shibuya.   

Abstract

Enediyne model compounds possessing photo-triggering devices were developed. These enediynes afforded biradicals by UV irradiation and showed DNA cleaving activity. The DNA damage was confirmed to be mainly caused by the biradical, not singlet oxygen.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 15125968     DOI： 10.1016/j.bmcl.2004.02.096

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Identification of the adduct between a 4-Aza-3-ene-1,6-diyne and DNA using electrospray ionization mass spectrometry.

Authors:  Courtney L Sherman; Sarah E Pierce; Jennifer S Brodbelt; Bodin Tuesuwan; Sean M Kerwin
Journal:  J Am Soc Mass Spectrom       Date:  2006-07-26       Impact factor: 3.109

2.  Generation and characterization of a distonic biradical anion formed from an enediynone prodrug in the gas phase.

Authors:  Linan Yang; Tefsit Bekele; Mark A Lipton; Hilkka I Kenttämaa
Journal:  J Am Soc Mass Spectrom       Date:  2013-03-20       Impact factor: 3.109
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.