| Literature DB >> 15125964 |
Mark T Bilodeau1, Leonard D Rodman, Georgia B McGaughey, Kathleen E Coll, Timothy J Koester, William F Hoffman, Randall W Hungate, Richard L Kendall, Rosemary C McFall, Keith W Rickert, Ruth Z Rutledge, Kenneth A Thomas.
Abstract
An azo-dye lead was modified to a novel N-(1,3-thiazol-2-yl)pyridin-2-amine series of KDR kinase inhibitors through the use of rapid analog libraries. This new class has been found to be potent, selective, and of low molecular weight. Molecular modeling has postulated an interesting conformational preference and binding mode for these compounds in the active site of the enzyme.Entities:
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Year: 2004 PMID： 15125964 DOI： 10.1016/j.bmcl.2004.03.052
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823