| Literature DB >> 15125962 |
Sergio Romeo1, Mario Dell'Agli, Silvia Parapini, Luca Rizzi, Germana Galli, Monica Mondani, Anna Sparatore, Donatella Taramelli, Enrica Bosisio.
Abstract
Statine-based inhibitors of Plasmepsin II (PLMII) coupled with Primaquine have been designed using the 'double-drug' approach. The IC50 values for PLMII inhibition ranged from 0.59 to 400 nM and the best IC50 value for inhibition of Plasmodium falciparum growth in vitro was 0.4 microM, which represent a remarkable improvement compared to other statine-based PLMII inhibitors.Entities:
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Year: 2004 PMID： 15125962 DOI： 10.1016/j.bmcl.2004.03.030
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823