| Literature DB >> 15125945 |
Belinda M Abbott1, Philip E Thompson.
Abstract
Synthetic 2-morpholinochromones, including the known PI3-kinase inhibitor LY294002, have been evaluated in vitro as inhibitors of isolated human platelet phosphodiesterases. Inhibition of the cAMP-phosphodiesterases, PDE2 and PDE3 by LY294002 is reported for the first time. Preliminary screening across a range of 2-morpholinochromones has revealed structural features for optimised PDE2 inhibition.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15125945 DOI： 10.1016/j.bmcl.2004.03.043
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823