| Literature DB >> 15125936 |
Marc Nazaré1, Hans Matter, Otmar Klingler, Fahad Al-Obeidi, Herman Schreuder, Gerhard Zoller, Jörg Czech, Martin Lorenz, Angela Dudda, Anusch Peyman, Hans Peter Nestler, Matthias Urmann, Armin Bauer, Volker Laux, Volkmar Wehner, David W Will.
Abstract
A series of novel, highly potent, achiral factor Xa inhibitors based on a benzoic acid scaffold and containing a chlorophenethyl moiety directed towards the protease S1 pocket is described. A number of structural features, such as the requirements of the P1, P4 and ester-binding pocket ligands were explored with respect to inhibition of factor Xa. Compound 46 was found to be the most potent compound in a series of antithrombotic secondary assays.Entities:
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Year: 2004 PMID： 15125936 DOI： 10.1016/j.bmcl.2004.03.059
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823