| Literature DB >> 15125927 |
Ana Montero1, Mercedes Alonso, Esperanza Benito, Antonio Chana, Enrique Mann, José M Navas, Bernardo Herradón.
Abstract
With the objective to understand structural features responsible for the biological activity, novel nonelectrophilic biphenyl derivatives and peptide-biphenyl hybrids have been synthesized and evaluated as calpain I inhibitors. The preliminary results indicate that the presence of additional aromatic rings (besides the biphenyl system) makes these compounds potent calpain inhibitors with IC50 values in the nanomolar range.Mesh：
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Year: 2004 PMID： 15125927 DOI： 10.1016/j.bmcl.2004.03.071
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823