Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A novel role of Mgm1p, a dynamin-related GTPase, in ATP synthase assembly and cristae formation/maintenance.

Literature DB >> 15125685

A novel role of Mgm1p, a dynamin-related GTPase, in ATP synthase assembly and cristae formation/maintenance.

Boominathan Amutha¹, Donna M Gordon, Yajuan Gu, Debkumar Pain.

Abstract

In Saccharomyces cerevisiae, two mitochondrial inner-membrane proteins play critical roles in organellar morphology. One is a dynamin-related GTPase, Mgm1p, which participates in mitochondrial fusion. Another is Tim11p, which is required for oligomeric assembly of F1Fo-ATP synthase, which generates ATP through oxidative phosphorylation. Our data bring these findings together and define a novel role for Mgm1p in the formation and maintenance of mitochondrial cristae. We show that Mgm1p serves as an upstream regulator of Tim11p protein stability, ATP synthase assembly, cristae morphology and cytochrome c storage within cristae.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2004 PMID： 15125685 PMCID： PMC1133757 DOI： 10.1042/BJ20040566

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

28 in total

Review 1. Mitochondrial dynamics and division in budding yeast.

Authors: Janet M Shaw; Jodi Nunnari
Journal: Trends Cell Biol Date: 2002-04 Impact factor: 20.808

2. The ATP synthase is involved in generating mitochondrial cristae morphology.

Authors: Patrick Paumard; Jacques Vaillier; Bénédicte Coulary; Jacques Schaeffer; Vincent Soubannier; David M Mueller; Daniel Brèthes; Jean-Paul di Rago; Jean Velours
Journal: EMBO J Date: 2002-02-01 Impact factor: 11.598

3. Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis.

Authors: Aurélien Olichon; Laurent Baricault; Nicole Gas; Emmanuelle Guillou; Annie Valette; Pascale Belenguer; Guy Lenaers
Journal: J Biol Chem Date: 2002-12-31 Impact factor: 5.157

Review 4. Intramembrane proteolysis controls diverse signalling pathways throughout evolution.

Authors: Sinisa Urban; Matthew Freeman
Journal: Curr Opin Genet Dev Date: 2002-10 Impact factor: 5.578

5. The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast.

Authors: W Bleazard; J M McCaffery; E J King; S Bale; A Mozdy; Q Tieu; J Nunnari; J M Shaw
Journal: Nat Cell Biol Date: 1999-09 Impact factor: 28.824

6. Su e of the yeast F1Fo-ATP synthase forms homodimers.

Authors: Susanne Brunner; Valerie Everard-Gigot; Rosemary A Stuart
Journal: J Biol Chem Date: 2002-10-10 Impact factor: 5.157

7. Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy.

Authors: C Delettre; G Lenaers; J M Griffoin; N Gigarel; C Lorenzo; P Belenguer; L Pelloquin; J Grosgeorge; C Turc-Carel; E Perret; C Astarie-Dequeker; L Lasquellec; B Arnaud; B Ducommun; J Kaplan; C P Hamel
Journal: Nat Genet Date: 2000-10 Impact factor: 38.330

8. OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28.

Authors: C Alexander; M Votruba; U E Pesch; D L Thiselton; S Mayer; A Moore; M Rodriguez; U Kellner; B Leo-Kottler; G Auburger; S S Bhattacharya; B Wissinger
Journal: Nat Genet Date: 2000-10 Impact factor: 38.330

9. The dynamin-related GTPase, Mgm1p, is an intermembrane space protein required for maintenance of fusion competent mitochondria.

Authors: E D Wong; J A Wagner; S W Gorsich; J M McCaffery; J M Shaw; J Nunnari
Journal: J Cell Biol Date: 2000-10-16 Impact factor: 10.539

10. The intramitochondrial dynamin-related GTPase, Mgm1p, is a component of a protein complex that mediates mitochondrial fusion.

Authors: Edith D Wong; Jennifer A Wagner; Sidney V Scott; Voytek Okreglak; Timothy J Holewinske; Ann Cassidy-Stone; Jodi Nunnari
Journal: J Cell Biol Date: 2003-02-03 Impact factor: 10.539

26 in total

1. Neurolastin, a dynamin family GTPase, translocates to mitochondria upon neuronal stress and alters mitochondrial morphology in vivo.

Authors: Richa Madan Lomash; Ronald S Petralia; Lynne A Holtzclaw; Mumeko C Tsuda; Ya-Xian Wang; John D Badger; Heather A Cameron; Richard J Youle; Katherine W Roche
Journal: J Biol Chem Date: 2019-06-07 Impact factor: 5.157

2. OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand.

Authors: David A Patten; Jacob Wong; Mireille Khacho; Vincent Soubannier; Ryan J Mailloux; Karine Pilon-Larose; Jason G MacLaurin; David S Park; Heidi M McBride; Laura Trinkle-Mulcahy; Mary-Ellen Harper; Marc Germain; Ruth S Slack
Journal: EMBO J Date: 2014-10-08 Impact factor: 11.598

Review 3. Structural diversity of mitochondria: functional implications.

Authors: Carmen A Mannella
Journal: Ann N Y Acad Sci Date: 2008-12 Impact factor: 5.691

4. Stepwise assembly of dimeric F(1)F(o)-ATP synthase in mitochondria involves the small F(o)-subunits k and i.

Authors: Karina Wagner; Inge Perschil; Christiane D Fichter; Martin van der Laan
Journal: Mol Biol Cell Date: 2010-03-10 Impact factor: 4.138

Review 5. Morphological dynamics of mitochondria--a special emphasis on cardiac muscle cells.

Authors: Jennifer Hom; Shey-Shing Sheu
Journal: J Mol Cell Cardiol Date: 2009-03-09 Impact factor: 5.000

Review 6. The connection between inner membrane topology and mitochondrial function.

Authors: Carmen A Mannella; W Jonathan Lederer; M Saleet Jafri
Journal: J Mol Cell Cardiol Date: 2013-05-12 Impact factor: 5.000

7. Mitochondrial complex II dysfunction can contribute significantly to genomic instability after exposure to ionizing radiation.

Authors: Disha Dayal; Sean M Martin; Kjerstin M Owens; Nukhet Aykin-Burns; Yueming Zhu; Amutha Boominathan; Debkumar Pain; Charles L Limoli; Prabhat C Goswami; Frederick E Domann; Douglas R Spitz
Journal: Radiat Res Date: 2009-12 Impact factor: 2.841