Louise M O'Brien1, Riva Tauman, David Gozal. 1. Kosair Children's Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, KY 40202, USA.
Abstract
STUDY OBJECTIVES: Sleep architecture is not preserved in children with sleep-disordered breathing but, rather, undergoes dynamic changes that exhibit significant correlation with severity of sleep-disordered breathing. A sleep pressure score (SPS) with a cutoff value of 0.25 was derived from analysis of a large cohort of snoring and control children. Neurocognitive batteries were applied to examine the potential effect of SPS. DESIGN: Prospective study. PARTICIPANTS: 199 children who underwent a battery of neurobehavioral tests following an overnight sleep study were assigned to SPSHigh (> or = 0.25) or SPSLow (< 0.25) groups, and their neurocognitive performances were compared. RESULTS: Children in the SPSHigh group were significantly more likely to have deficits in memory, language abilities, verbal abilities, and some visuospatial functions than were children in the SPSLow group. These effects remained highly significant after adjusting for confounding variables and exhibited small to moderate effect sizes. CONCLUSIONS: We conclude that a sleep-pressure numerical factor derived from the overnight polysomnogram in snoring children is associated with deficits in neurobehavioral daytime functions that is independent of respiratory disturbance and hypoxemia and suggests a significant role for disturbed sleep homeostasis in pediatric sleep-disordered breathing.
STUDY OBJECTIVES: Sleep architecture is not preserved in children with sleep-disordered breathing but, rather, undergoes dynamic changes that exhibit significant correlation with severity of sleep-disordered breathing. A sleep pressure score (SPS) with a cutoff value of 0.25 was derived from analysis of a large cohort of snoring and control children. Neurocognitive batteries were applied to examine the potential effect of SPS. DESIGN: Prospective study. PARTICIPANTS: 199 children who underwent a battery of neurobehavioral tests following an overnight sleep study were assigned to SPSHigh (> or = 0.25) or SPSLow (< 0.25) groups, and their neurocognitive performances were compared. RESULTS:Children in the SPSHigh group were significantly more likely to have deficits in memory, language abilities, verbal abilities, and some visuospatial functions than were children in the SPSLow group. These effects remained highly significant after adjusting for confounding variables and exhibited small to moderate effect sizes. CONCLUSIONS: We conclude that a sleep-pressure numerical factor derived from the overnight polysomnogram in snoring children is associated with deficits in neurobehavioral daytime functions that is independent of respiratory disturbance and hypoxemia and suggests a significant role for disturbed sleep homeostasis in pediatric sleep-disordered breathing.
Authors: David Gozal; Laura D Serpero; Leila Kheirandish-Gozal; Oscar Sans Capdevila; Abdelnaby Khalyfa; Riva Tauman Journal: Sleep Date: 2010-03 Impact factor: 5.849
Authors: Joel S C Yang; Christian L Nicholas; Gillian M Nixon; Margot J Davey; Vicki Anderson; Adrian M Walker; John Trinder; Rosemary S C Horne Journal: Sleep Breath Date: 2011-05-13 Impact factor: 2.816
Authors: Sushmita Pamidi; Susan Redline; David Rapoport; Indu Ayappa; Luciana Palombini; Ramon Farre; Jason Kirkness; Jean-Louis Pépin; Olli Polo; Andrew Wellman; R John Kimoff Journal: Ann Am Thorac Soc Date: 2017-07
Authors: Ronald D Chervin; Susan L Garetz; Deborah L Ruzicka; Elise K Hodges; Bruno J Giordani; James E Dillon; Barbara T Felt; Timothy F Hoban; Kenneth E Guire; Louise M O'Brien; Joseph W Burns Journal: J Clin Sleep Med Date: 2014-08-15 Impact factor: 4.062
Authors: Ronald D Chervin; Deborah L Ruzicka; Bruno J Giordani; Robert A Weatherly; James E Dillon; Elise K Hodges; Carole L Marcus; Kenneth E Guire Journal: Pediatrics Date: 2006-04 Impact factor: 7.124