OBJECTIVE: To determine and contrast the disease activity and clinical variables between Hispanic and Caucasian patients with systemic lupus erythematosus (SLE) in New Mexico. METHODS: Socioeconomic-demographic and clinical data were collected from 125 SLE patients by an interview-administered questionnaire. The Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) was used to assess disease activity. RESULTS: Seventy-four Hispanics (H) and 40 Caucasians (C) were compared. Demographics including age, gender, disease duration, marital status, and cigarette smoking were similar between the 2 groups. However, education and income were higher in the Caucasian group compared to the Hispanic group. There was no significant difference between the 2 groups in overall disease activity as measured by the SLEDAI. However, when individual components of the SLEDAI were compared, Hispanics had an increased prevalence of arthritis (77% vs 51%, p = 0.01) and depressed complement levels (40% vs 18%, p = 0.02). Moreover, corticosteroid use was higher among the Hispanics compared to the Caucasian population (p = 0.03). CONCLUSION: We found similar levels of overall disease activity in Hispanic and Caucasian patients with SLE. However, Hispanics used more corticosteroids, had a greater prevalence of arthritis, and had depressed complement levels indicating increased SLE disease activity highly restricted to specific domains. It remains to be determined whether these restricted but discrete differences are genetic in origin, or are related cultural or environmental factors.
OBJECTIVE: To determine and contrast the disease activity and clinical variables between Hispanic and Caucasian patients with systemic lupus erythematosus (SLE) in New Mexico. METHODS: Socioeconomic-demographic and clinical data were collected from 125 SLEpatients by an interview-administered questionnaire. The Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) was used to assess disease activity. RESULTS: Seventy-four Hispanics (H) and 40 Caucasians (C) were compared. Demographics including age, gender, disease duration, marital status, and cigarette smoking were similar between the 2 groups. However, education and income were higher in the Caucasian group compared to the Hispanic group. There was no significant difference between the 2 groups in overall disease activity as measured by the SLEDAI. However, when individual components of the SLEDAI were compared, Hispanics had an increased prevalence of arthritis (77% vs 51%, p = 0.01) and depressed complement levels (40% vs 18%, p = 0.02). Moreover, corticosteroid use was higher among the Hispanics compared to the Caucasian population (p = 0.03). CONCLUSION: We found similar levels of overall disease activity in Hispanic and Caucasian patients with SLE. However, Hispanics used more corticosteroids, had a greater prevalence of arthritis, and had depressed complement levels indicating increased SLE disease activity highly restricted to specific domains. It remains to be determined whether these restricted but discrete differences are genetic in origin, or are related cultural or environmental factors.
Authors: Elena Sanchez; Ryan D Webb; Astrid Rasmussen; Jennifer A Kelly; Laura Riba; Kenneth M Kaufman; Ignacio Garcia-de la Torre; Jose F Moctezuma; Marco A Maradiaga-Ceceña; Mario H Cardiel-Rios; Eduardo Acevedo; Mariano Cucho-Venegas; Mercedes A Garcia; Susana Gamron; Bernardo A Pons-Estel; Carlos Vasconcelos; Javier Martin; Teresa Tusié-Luna; John B Harley; Bruce Richardson; Amr H Sawalha; Marta E Alarcón-Riquelme Journal: Arthritis Rheum Date: 2010-12
Authors: Elena Sánchez; Astrid Rasmussen; Laura Riba; Eduardo Acevedo-Vasquez; Jennifer A Kelly; Carl D Langefeld; Adrianne H Williams; Julie T Ziegler; Mary E Comeau; Miranda C Marion; Ignacio García-De La Torre; Marco A Maradiaga-Ceceña; Mario H Cardiel; Jorge A Esquivel-Valerio; Jacqueline Rodriguez-Amado; José Francisco Moctezuma; Pedro Miranda; Carlos E Perandones; Cecilia Castel; Hugo A Laborde; Paula Alba; Jorge L Musuruana; I Annelise Goecke; Juan-Manuel Anaya; Kenneth M Kaufman; Adam Adler; Stuart B Glenn; Elizabeth E Brown; Graciela S Alarcón; Robert P Kimberly; Jeffrey C Edberg; Luis M Vilá; Lindsey A Criswell; Gary S Gilkeson; Timothy B Niewold; Javier Martín; Timothy J Vyse; Susan A Boackle; Rosalind Ramsey-Goldman; R Hal Scofield; Michelle Petri; Joan T Merrill; John D Reveille; Betty P Tsao; Lorena Orozco; Vicente Baca; Kathy L Moser; Patrick M Gaffney; Judith A James; John B Harley; Teresa Tusié-Luna; Bernardo A Pons-Estel; Chaim O Jacob; Marta E Alarcón-Riquelme Journal: Arthritis Rheum Date: 2012-11
Authors: Hong Sang Choi; Kyung-Do Han; Jin-Hyung Jung; Chang Seong Kim; Eun Hui Bae; Seong Kwon Ma; Soo Wan Kim Journal: Medicine (Baltimore) Date: 2019-07 Impact factor: 1.817
Authors: Joseph S Massias; Eve Md Smith; Eslam Al-Abadi; Kate Armon; Kathryn Bailey; Coziana Ciurtin; Joyce Davidson; Janet Gardner-Medwin; Kirsty Haslam; Dan P Hawley; Alice Leahy; Valentina Leone; Flora McErlane; Devesh Mewar; Gita Modgil; Robert Moots; Clarissa Pilkington; Athimalaipet V Ramanan; Satyapal Rangaraj; Phil Riley; Arani Sridhar; Nick Wilkinson; Michael W Beresford; Christian M Hedrich Journal: Lupus Date: 2021-01-07 Impact factor: 2.911