Literature DB >> 15124095

Geniposide, an anti-angiogenic compound from the fruits of Gardenia jasminoides.

Hye-Jin Koo1, Sanghyun Lee, Kuk-Hyun Shin, Byung-Chul Kim, Chang-Jin Lim, Eun-Hee Park.   

Abstract

The EtOH extract of gardenia (Gardenia jasminoides Ellis) fruits was previously found to possess potent anti-angiogenic activity in the chick embryo chorioallantoic membrane (CAM) assay. Bioassay-guided fractionation and purification of the EtOH extract yielded an active anti-angiogenic compound, which was determined to be an iridoid glucoside, geniposide, by spectral analyses. Geniposide showed anti-angiogenic activity in a dose-dependent manner. It also exhibited an inhibitory effect in the range of 25-100 microM on the growth of the transformed NIH3T3 cell line.

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Year:  2004        PMID： 15124095     DOI： 10.1055/s-2004-818978

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  21 in total

1.  GLP-1 receptor plays a critical role in geniposide-induced expression of heme oxygenase-1 in PC12 cells.

Authors:  Fei Yin; Jian-hui Liu; Xu-xu Zheng; Li-xia Guo
Journal:  Acta Pharmacol Sin       Date:  2010-04-05       Impact factor: 6.150

2.  Comprehensive metabolome analysis for the pharmacological action of inchinkoto, a hepatoprotective herbal medicine.

Authors:  Hiromasa Yamashita; Katsuya Ohbuchi; Masato Nagino; Tomoki Ebata; Kazuaki Tsuchiya; Hirotaka Kushida; Yukihiro Yokoyama
Journal:  Metabolomics       Date:  2021-12-02       Impact factor: 4.290

3.  Geniposide inhibits interleukin-6 and interleukin-8 production in lipopolysaccharide-induced human umbilical vein endothelial cells by blocking p38 and ERK1/2 signaling pathways.

Authors:  Hong-Tao Liu; Jun-Lin He; Wen-Ming Li; Zhu Yang; Ying-Xiong Wang; Juan Yin; Yu-Guang Du; Chao Yu
Journal:  Inflamm Res       Date:  2009-11-29       Impact factor: 4.575

4.  Monoamine Oxidase and Dopamine β-Hydroxylase Inhibitors from the Fruits of Gardenia jasminoides.

Authors:  Ji Ho Kim; Gun Hee Kim; Keum Hee Hwang
Journal:  Biomol Ther (Seoul)       Date:  2012-03       Impact factor: 4.634

5.  Protective Effects of Geniposide and Genipin against Hepatic Ischemia/Reperfusion Injury in Mice.

Authors:  Joonki Kim; Hyo-Yeon Kim; Sun-Mee Lee
Journal:  Biomol Ther (Seoul)       Date:  2013-03       Impact factor: 4.634

6.  Geniposide prevents rotenone-induced apoptosis in primary cultured neurons.

Authors:  Lin Li; Juan Zhao; Ke Liu; Guang-Lai Li; Yan-Qing Han; Yue-Ze Liu
Journal:  Neural Regen Res       Date:  2015-10       Impact factor: 5.135

7.  Anti-Inflammatory Effect of Geniposide on Osteoarthritis by Suppressing the Activation of p38 MAPK Signaling Pathway.

Authors:  Yuan Chen; Kangquan Shou; Chunlong Gong; Huarui Yang; Yi Yang; Tongzhu Bao
Journal:  Biomed Res Int       Date:  2018-02-26       Impact factor: 3.411

8.  Enhancement of active compound, genipin, from Gardeniae Fructus using immobilized glycosyl hydrolase family 3 β-glucosidase from Lactobacillus antri.

Authors:  Young Soo Kim; Chung-Jo Lee; Jin Yeul Ma
Journal:  AMB Express       Date:  2017-03-16       Impact factor: 3.298

9.  Identification and determination of the major constituents in traditional Chinese medicine Longdan Xiegan Pill by HPLC-DAD-ESI-MS.

Authors:  Hui Liu; Juan Su; Xu Liang; Xi Zhang; Ya-Jun He; Hai-Qiang Huang; Ji Ye; Wei-Dong Zhang
Journal:  J Pharm Anal       Date:  2012-01-30

10.  An effective solution to discover synergistic drugs for anti-cerebral ischemia from traditional Chinese medicinal formulae.

Authors:  Shaojing Li; Chuanhong Wu; Jianxin Chen; Peng Lu; Chang Chen; Meihong Fu; Jing Fang; Jian Gao; Li Zhu; Rixin Liang; Xin Shen; Hongjun Yang
Journal:  PLoS One       Date:  2013-11-13       Impact factor: 3.240
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