Literature DB >> 15124015

Dysbindin-1 and schizophrenia: from genetics to neuropathology.

Michael J Owen1, Nigel M Williams, Michael C O'Donovan.   

Abstract

The gene encoding dysbindin-1 has recently been implicated in susceptibility to schizophrenia. In this issue of the JCI, Talbot et al. show that, contrary to expectations, dysbindin-1 is located presynaptically in glutamatergic neurons and is reduced at these locations in schizophrenia. Further studies of dysbindin-1 and the proteins with which it interacts can be expected to throw light on the pathogenesis of schizophrenia.

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Year:  2004        PMID： 15124015      PMCID： PMC398436          DOI： 10.1172/JCI21470

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  13 in total

1.  Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families.

Authors:  Sibylle G Schwab; Michael Knapp; Stephanie Mondabon; Joachim Hallmayer; Margitta Borrmann-Hassenbach; Margot Albus; Bernard Lerer; Marcella Rietschel; Matyas Trixler; Wolfgang Maier; Dieter B Wildenauer
Journal:  Am J Hum Genet       Date:  2002-12-09       Impact factor: 11.025

Review 2.  Bringing order to the glutamate chaos in schizophrenia.

Authors:  Bita Moghaddam
Journal:  Neuron       Date:  2003-12-04       Impact factor: 17.173

3.  Cis-acting variation in the expression of a high proportion of genes in human brain.

Authors:  Nicholas J Bray; Paul R Buckland; Michael J Owen; Michael C O'Donovan
Journal:  Hum Genet       Date:  2003-05-01       Impact factor: 4.132

Review 4.  Recent advances in the genetics of schizophrenia.

Authors:  Michael C O'Donovan; Nigel M Williams; Michael J Owen
Journal:  Hum Mol Genet       Date:  2003-09-02       Impact factor: 6.150

5.  Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain.

Authors:  M A Benson; S E Newey; E Martin-Rendon; R Hawkes; D J Blake
Journal:  J Biol Chem       Date:  2001-04-20       Impact factor: 5.157

Review 6.  The neuropathology of schizophrenia. A critical review of the data and their interpretation.

Authors:  P J Harrison
Journal:  Brain       Date:  1999-04       Impact factor: 13.501

Review 7.  Genes for schizophrenia? Recent findings and their pathophysiological implications.

Authors:  Paul J Harrison; Michael J Owen
Journal:  Lancet       Date:  2003-02-01       Impact factor: 79.321

8.  Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia.

Authors:  Richard E Straub; Yuxin Jiang; Charles J MacLean; Yunlong Ma; Bradley T Webb; Maxim V Myakishev; Carole Harris-Kerr; Brandon Wormley; Hannah Sadek; Bharat Kadambi; Anthony J Cesare; Avi Gibberman; Xu Wang; F Anthony O'Neill; Dermot Walsh; Kenneth S Kendler
Journal:  Am J Hum Genet       Date:  2002-07-03       Impact factor: 11.025

9.  Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1).

Authors:  Wei Li; Qing Zhang; Naoki Oiso; Edward K Novak; Rashi Gautam; Edward P O'Brien; Caroline L Tinsley; Derek J Blake; Richard A Spritz; Neal G Copeland; Nancy A Jenkins; Dominick Amato; Bruce A Roe; Marta Starcevic; Esteban C Dell'Angelica; Rosemary W Elliott; Vishnu Mishra; Stephen F Kingsmore; Richard E Paylor; Richard T Swank
Journal:  Nat Genet       Date:  2003-08-17       Impact factor: 38.330

10.  Different dystrophin-like complexes are expressed in neurons and glia.

Authors:  D J Blake; R Hawkes; M A Benson; P W Beesley
Journal:  J Cell Biol       Date:  1999-11-01       Impact factor: 10.539
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  17 in total

1.  Nucleocytoplasmic shuttling of dysbindin-1, a schizophrenia-related protein, regulates synapsin I expression.

Authors:  Erkang Fei; Xiaochuan Ma; Cuiqing Zhu; Ting Xue; Jie Yan; Yuxia Xu; Jiangning Zhou; Guanghui Wang
Journal:  J Biol Chem       Date:  2010-10-04       Impact factor: 5.157

Review 2.  Schizophrenia: an update and review.

Authors:  Jehannine Austin
Journal:  J Genet Couns       Date:  2005-10       Impact factor: 2.537

3.  GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia.

Authors:  X Chen; G Lee; B S Maher; A H Fanous; J Chen; Z Zhao; A Guo; E van den Oord; P F Sullivan; J Shi; D F Levinson; P V Gejman; A Sanders; J Duan; M J Owen; N J Craddock; M C O'Donovan; J Blackman; D Lewis; G K Kirov; W Qin; S Schwab; D Wildenauer; K Chowdari; V Nimgaonkar; R E Straub; D R Weinberger; F A O'Neill; D Walsh; M Bronstein; A Darvasi; T Lencz; A K Malhotra; D Rujescu; I Giegling; T Werge; T Hansen; A Ingason; M M Nöethen; M Rietschel; S Cichon; S Djurovic; O A Andreassen; R M Cantor; R Ophoff; A Corvin; D W Morris; M Gill; C N Pato; M T Pato; A Macedo; H M D Gurling; A McQuillin; J Pimm; C Hultman; P Lichtenstein; P Sklar; S M Purcell; E Scolnick; D St Clair; D H R Blackwood; K S Kendler
Journal:  Mol Psychiatry       Date:  2010-09-14       Impact factor: 15.992

4.  TRIM24 protein promotes and TRIM32 protein inhibits cardiomyocyte hypertrophy via regulation of dysbindin protein levels.

Authors:  Ankush Borlepawar; Ashraf Yusuf Rangrez; Alexander Bernt; Lynn Christen; Samuel Sossalla; Derk Frank; Norbert Frey
Journal:  J Biol Chem       Date:  2017-05-02       Impact factor: 5.157

5.  The 2nd Schizophrenia International Research Society Conference, 10-14 April 2010, Florence, Italy: summaries of oral sessions.

Authors:  Moogeh Baharnoori; Cali Bartholomeusz; Aurelie A Boucher; Lisa Buchy; Christopher Chaddock; Bonga Chiliza; Melanie Föcking; Alex Fornito; Juan A Gallego; Hiroaki Hori; Gisele Huf; Gul A Jabbar; Shi Hyun Kang; Yousri El Kissi; Jessica Merchán-Naranjo; Gemma Modinos; Nashaat A M Abdel-Fadeel; Anna-Karin Neubeck; Hsiao Piau Ng; Gabriela Novak; Olasunmbo O Owolabi; Diana P Prata; Naren P Rao; Igor Riecansky; Darryl C Smith; Renan P Souza; Renate Thienel; Hanan D Trotman; Hiroyuki Uchida; Kristen A Woodberry; Anne O'Shea; Lynn E DeLisi
Journal:  Schizophr Res       Date:  2010-10-08       Impact factor: 4.939

6.  DTNBP1 (Dystrobrevin binding protein 1) and schizophrenia: association evidence in the 3' end of the gene.

Authors:  Jubao Duan; Maria Martinez; Alan R Sanders; Cuiping Hou; Gregory J Burrell; Aaron J Krasner; Daniel B Schwartz; Pablo V Gejman
Journal:  Hum Hered       Date:  2007-05-02       Impact factor: 0.444

7.  The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis.

Authors:  Dion K Dickman; Graeme W Davis
Journal:  Science       Date:  2009-11-20       Impact factor: 47.728

8.  The effects of a DTNBP1 gene variant on attention networks: an fMRI study.

Authors:  Markus Thimm; Axel Krug; Thilo Kellermann; Valentin Markov; Sören Krach; Andreas Jansen; Klaus Zerres; Thomas Eggermann; Tony Stöcker; N Jon Shah; Markus M Nöthen; Marcella Rietschel; Tilo Kircher
Journal:  Behav Brain Funct       Date:  2010-09-16       Impact factor: 3.759

9.  The impact of dystrobrevin-binding protein 1 (DTNBP1) on neural correlates of episodic memory encoding and retrieval.

Authors:  Markus Thimm; Axel Krug; Valentin Markov; Sören Krach; Andreas Jansen; Klaus Zerres; Thomas Eggermann; Tony Stöcker; Nadim Jon Shah; Markus M Nöthen; Marcella Rietschel; Tilo Kircher
Journal:  Hum Brain Mapp       Date:  2010-02       Impact factor: 5.038

10.  Impact of schizophrenia-risk gene dysbindin 1 on brain activation in bilateral middle frontal gyrus during a working memory task in healthy individuals.

Authors:  Valentin Markov; Axel Krug; Sören Krach; Andreas Jansen; Thomas Eggermann; Karl Zerres; Tony Stöcker; N Jon Shah; Markus M Nöthen; Jens Treutlein; Marcella Rietschel; Tilo Kircher
Journal:  Hum Brain Mapp       Date:  2010-02       Impact factor: 5.038
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