Literature DB >> 15123810

The diploid genome sequence of Candida albicans.

Ted Jones1, Nancy A Federspiel, Hiroji Chibana, Jan Dungan, Sue Kalman, B B Magee, George Newport, Yvonne R Thorstenson, Nina Agabian, P T Magee, Ronald W Davis, Stewart Scherer.   

Abstract

We present the diploid genome sequence of the fungal pathogen Candida albicans. Because C. albicans has no known haploid or homozygous form, sequencing was performed as a whole-genome shotgun of the heterozygous diploid genome in strain SC5314, a clinical isolate that is the parent of strains widely used for molecular analysis. We developed computational methods to assemble a diploid genome sequence in good agreement with available physical mapping data. We provide a whole-genome description of heterozygosity in the organism. Comparative genomic analyses provide important clues about the evolution of the species and its mechanisms of pathogenesis.

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Year:  2004        PMID： 15123810      PMCID： PMC409918          DOI： 10.1073/pnas.0401648101

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  24 in total

1.  Induction of mating in Candida albicans by construction of MTLa and MTLalpha strains.

Authors:  B B Magee; P T Magee
Journal:  Science       Date:  2000-07-14       Impact factor: 47.728

2.  Allele-specific gene targeting in Candida albicans results from heterology between alleles.

Authors:  Kyle Yesland; William A Fonzi
Journal:  Microbiology (Reading)       Date:  2000-09       Impact factor: 2.777

3.  RIM101-dependent and-independent pathways govern pH responses in Candida albicans.

Authors:  D Davis; R B Wilson; A P Mitchell
Journal:  Mol Cell Biol       Date:  2000-02       Impact factor: 4.272

4.  A high-affinity iron permease essential for Candida albicans virulence.

Authors:  N Ramanan; Y Wang
Journal:  Science       Date:  2000-05-12       Impact factor: 47.728

5.  Secreted lipases of Candida albicans: cloning, characterisation and expression analysis of a new gene family with at least ten members.

Authors:  B Hube; F Stehr; M Bossenz; A Mazur; M Kretschmar; W Schäfer
Journal:  Arch Microbiol       Date:  2000-11       Impact factor: 2.552

6.  Evidence for mating of the "asexual" yeast Candida albicans in a mammalian host.

Authors:  C M Hull; R M Raisner; A D Johnson
Journal:  Science       Date:  2000-07-14       Impact factor: 47.728

7.  Multiple LTR-retrotransposon families in the asexual yeast Candida albicans.

Authors:  T J Goodwin; R T Poulter
Journal:  Genome Res       Date:  2000-02       Impact factor: 9.043

8.  Fine-resolution physical mapping of genomic diversity in Candida albicans.

Authors:  H Chibana; J L Beckerman; P T Magee
Journal:  Genome Res       Date:  2000-12       Impact factor: 9.043

9.  Prevalence of small inversions in yeast gene order evolution.

Authors:  C Seoighe; N Federspiel; T Jones; N Hansen; V Bivolarovic; R Surzycki; R Tamse; C Komp; L Huizar; R W Davis; S Scherer; E Tait; D J Shaw; D Harris; L Murphy; K Oliver; K Taylor; M A Rajandream; B G Barrell; K H Wolfe
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-19       Impact factor: 11.205

10.  The sequence of the human genome.

Authors:  J C Venter; M D Adams; E W Myers; P W Li; R J Mural; G G Sutton; H O Smith; M Yandell; C A Evans; R A Holt; J D Gocayne; P Amanatides; R M Ballew; D H Huson; J R Wortman; Q Zhang; C D Kodira; X H Zheng; L Chen; M Skupski; G Subramanian; P D Thomas; J Zhang; G L Gabor Miklos; C Nelson; S Broder; A G Clark; J Nadeau; V A McKusick; N Zinder; A J Levine; R J Roberts; M Simon; C Slayman; M Hunkapiller; R Bolanos; A Delcher; I Dew; D Fasulo; M Flanigan; L Florea; A Halpern; S Hannenhalli; S Kravitz; S Levy; C Mobarry; K Reinert; K Remington; J Abu-Threideh; E Beasley; K Biddick; V Bonazzi; R Brandon; M Cargill; I Chandramouliswaran; R Charlab; K Chaturvedi; Z Deng; V Di Francesco; P Dunn; K Eilbeck; C Evangelista; A E Gabrielian; W Gan; W Ge; F Gong; Z Gu; P Guan; T J Heiman; M E Higgins; R R Ji; Z Ke; K A Ketchum; Z Lai; Y Lei; Z Li; J Li; Y Liang; X Lin; F Lu; G V Merkulov; N Milshina; H M Moore; A K Naik; V A Narayan; B Neelam; D Nusskern; D B Rusch; S Salzberg; W Shao; B Shue; J Sun; Z Wang; A Wang; X Wang; J Wang; M Wei; R Wides; C Xiao; C Yan; A Yao; J Ye; M Zhan; W Zhang; H Zhang; Q Zhao; L Zheng; F Zhong; W Zhong; S Zhu; S Zhao; D Gilbert; S Baumhueter; G Spier; C Carter; A Cravchik; T Woodage; F Ali; H An; A Awe; D Baldwin; H Baden; M Barnstead; I Barrow; K Beeson; D Busam; A Carver; A Center; M L Cheng; L Curry; S Danaher; L Davenport; R Desilets; S Dietz; K Dodson; L Doup; S Ferriera; N Garg; A Gluecksmann; B Hart; J Haynes; C Haynes; C Heiner; S Hladun; D Hostin; J Houck; T Howland; C Ibegwam; J Johnson; F Kalush; L Kline; S Koduru; A Love; F Mann; D May; S McCawley; T McIntosh; I McMullen; M Moy; L Moy; B Murphy; K Nelson; C Pfannkoch; E Pratts; V Puri; H Qureshi; M Reardon; R Rodriguez; Y H Rogers; D Romblad; B Ruhfel; R Scott; C Sitter; M Smallwood; E Stewart; R Strong; E Suh; R Thomas; N N Tint; S Tse; C Vech; G Wang; J Wetter; S Williams; M Williams; S Windsor; E Winn-Deen; K Wolfe; J Zaveri; K Zaveri; J F Abril; R Guigó; M J Campbell; K V Sjolander; B Karlak; A Kejariwal; H Mi; B Lazareva; T Hatton; A Narechania; K Diemer; A Muruganujan; N Guo; S Sato; V Bafna; S Istrail; R Lippert; R Schwartz; B Walenz; S Yooseph; D Allen; A Basu; J Baxendale; L Blick; M Caminha; J Carnes-Stine; P Caulk; Y H Chiang; M Coyne; C Dahlke; A Deslattes Mays; M Dombroski; M Donnelly; D Ely; S Esparham; C Fosler; H Gire; S Glanowski; K Glasser; A Glodek; M Gorokhov; K Graham; B Gropman; M Harris; J Heil; S Henderson; J Hoover; D Jennings; C Jordan; J Jordan; J Kasha; L Kagan; C Kraft; A Levitsky; M Lewis; X Liu; J Lopez; D Ma; W Majoros; J McDaniel; S Murphy; M Newman; T Nguyen; N Nguyen; M Nodell; S Pan; J Peck; M Peterson; W Rowe; R Sanders; J Scott; M Simpson; T Smith; A Sprague; T Stockwell; R Turner; E Venter; M Wang; M Wen; D Wu; M Wu; A Xia; A Zandieh; X Zhu
Journal:  Science       Date:  2001-02-16       Impact factor: 47.728
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  310 in total

1.  Loss of heterozygosity at an unlinked genomic locus is responsible for the phenotype of a Candida albicans sap4Δ sap5Δ sap6Δ mutant.

Authors:  Nico Dunkel; Joachim Morschhäuser
Journal:  Eukaryot Cell       Date:  2010-11-19

2.  Rad52 function prevents chromosome loss and truncation in Candida albicans.

Authors:  E Andaluz; A Bellido; J Gómez-Raja; A Selmecki; K Bouchonville; R Calderone; J Berman; G Larriba
Journal:  Mol Microbiol       Date:  2011-01-27       Impact factor: 3.501

3.  Fungicidal monoclonal antibody C7 interferes with iron acquisition in Candida albicans.

Authors:  Sonia Brena; Jonathan Cabezas-Olcoz; María D Moragues; Iñigo Fernández de Larrinoa; Angel Domínguez; Guillermo Quindós; José Pontón
Journal:  Antimicrob Agents Chemother       Date:  2011-04-25       Impact factor: 5.191

Review 4.  Milestones in Candida albicans gene manipulation.

Authors:  Dhanushki P Samaranayake; Steven D Hanes
Journal:  Fungal Genet Biol       Date:  2011-04-14       Impact factor: 3.495

5.  Centromeric DNA sequences in the pathogenic yeast Candida albicans are all different and unique.

Authors:  Kaustuv Sanyal; Mary Baum; John Carbon
Journal:  Proc Natl Acad Sci U S A       Date:  2004-07-22       Impact factor: 11.205

Review 6.  Drosophila and Galleria insect model hosts: new tools for the study of fungal virulence, pharmacology and immunology.

Authors:  Michail S Lionakis
Journal:  Virulence       Date:  2011 Nov-Dec       Impact factor: 5.882

7.  Iron acquisition from transferrin by Candida albicans depends on the reductive pathway.

Authors:  Simon A B Knight; Gaston Vilaire; Emmanuel Lesuisse; Andrew Dancis
Journal:  Infect Immun       Date:  2005-09       Impact factor: 3.441

8.  Extensive chromosome rearrangements distinguish the karyotype of the hypovirulent species Candida dubliniensis from the virulent Candida albicans.

Authors:  B B Magee; Melissa D Sanchez; David Saunders; David Harris; M Berriman; P T Magee
Journal:  Fungal Genet Biol       Date:  2007-07-20       Impact factor: 3.495

9.  Roles of Candida albicans Sfl1 in hyphal development.

Authors:  Yandong Li; Chang Su; Xuming Mao; Fang Cao; Jiangye Chen
Journal:  Eukaryot Cell       Date:  2007-08-22

10.  High-throughput identification and quantification of Candida species using high resolution derivative melt analysis of panfungal amplicons.

Authors:  Tasneem Mandviwala; Rupali Shinde; Apoorv Kalra; Jack D Sobel; Robert A Akins
Journal:  J Mol Diagn       Date:  2009-12-10       Impact factor: 5.568
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