BACKGROUND: International evidence on the cost and effects of interventions for reducing the global burden of depression remain scarce. Aims To estimate the population-level cost-effectiveness of evidence-based depression interventions and their contribution towards reducing current burden. METHOD: Primary-care-based depression interventions were modelled at the level of whole populations in 14 epidemiological subregions of the world. Total population-level costs (in international dollars or I$) and effectiveness (disability adjusted life years (DALYs) averted) were combined to form average and incremental cost-effectiveness ratios. RESULTS: Evaluated interventions have the potential to reduce the current burden of depression by 10-30%. Pharmacotherapy with older antidepressant drugs, with or without proactive collaborative care, are currently more cost-effective strategies than those using newer antidepressants, particularly in lower-income subregions. CONCLUSIONS: Even in resource-poor regions, each DALYaverted by efficient depression treatments in primary care costs less than 1 year of average per capita income, making such interventions a cost-effective use of health resources. However, current levels of burden can only be reduced significantly if there is a substantial increase substantial increase in treatment coverage.
BACKGROUND: International evidence on the cost and effects of interventions for reducing the global burden of depression remain scarce. Aims To estimate the population-level cost-effectiveness of evidence-based depression interventions and their contribution towards reducing current burden. METHOD: Primary-care-based depression interventions were modelled at the level of whole populations in 14 epidemiological subregions of the world. Total population-level costs (in international dollars or I$) and effectiveness (disability adjusted life years (DALYs) averted) were combined to form average and incremental cost-effectiveness ratios. RESULTS: Evaluated interventions have the potential to reduce the current burden of depression by 10-30%. Pharmacotherapy with older antidepressant drugs, with or without proactive collaborative care, are currently more cost-effective strategies than those using newer antidepressants, particularly in lower-income subregions. CONCLUSIONS: Even in resource-poor regions, each DALYaverted by efficient depression treatments in primary care costs less than 1 year of average per capita income, making such interventions a cost-effective use of health resources. However, current levels of burden can only be reduced significantly if there is a substantial increase substantial increase in treatment coverage.
Authors: M Martin-Carrasco; S Evans-Lacko; G Dom; N G Christodoulou; J Samochowiec; E González-Fraile; P Bienkowski; M Gómez-Beneyto; M J H Dos Santos; D Wasserman Journal: Eur Arch Psychiatry Clin Neurosci Date: 2016-02-13 Impact factor: 5.270
Authors: Dan J Stein; Soraya Seedat; Allen Herman; Hashim Moomal; Steven G Heeringa; Ronald C Kessler; David R Williams Journal: Br J Psychiatry Date: 2008-02 Impact factor: 9.319
Authors: Eun Lee; Hyong Jin Cho; Richard Olmstead; Myron J Levin; Michael N Oxman; Michael R Irwin Journal: Sleep Date: 2013-11-01 Impact factor: 5.849