R Jay Turner1, Donald A Lloyd. 1. Center for Demography and Population Health, Department of Sociology, Florida State University, Tallahassee 32306-2240, USA. jturner@fsu.edu
Abstract
BACKGROUND: With the exception of studies of individual traumatic events, the significance of stress exposure in psychiatric disorder previously has not been effectively examined. OBJECTIVE: To address the hypothesis that accumulated adversity represents an important risk factor for the subsequent onset of depressive and anxiety disorders. DESIGN: A community-based study of psychiatric and substance use disorders among a large, ethnically diverse cohort representative of young adults in South Florida. Adversity was estimated with a count of major and potentially traumatic events experienced during one's lifetime and prior to the onset of disorder. SETTING: Most interviews took place in the homes of participants, with 30% conducted by telephone. PARTICIPANTS: We obtained a random sample of individuals aged 18 to 23 years from a previously studied representative sample of young adolescents. Because participants in the prior study were predominantly boys, a supplementary sample of girls was randomly obtained from the early-adolescence school class rosters. A total of 1803 interviews were completed, representing a success rate of 70.1%. MAIN OUTCOME MEASURES: Depressive and anxiety disorders were assessed through computer-assisted personal interviews using the DSM-IV version of the Michigan Composite International Diagnostic Interview. RESULTS: Level of lifetime exposure to adversity was found to be associated with an increased risk of subsequent onset of depressive and/or anxiety disorder. This association remained clearly observable when childhood conduct disorder, attention-deficit/hyperactivity disorder, prior substance dependence, and posttraumatic stress disorder were held constant and when the possibility of state dependence effects was considered. CONCLUSION: Evidence suggests that high levels of lifetime exposure to adversity are causally implicated in the onset of depressive and anxiety disorders.
BACKGROUND: With the exception of studies of individual traumatic events, the significance of stress exposure in psychiatric disorder previously has not been effectively examined. OBJECTIVE: To address the hypothesis that accumulated adversity represents an important risk factor for the subsequent onset of depressive and anxiety disorders. DESIGN: A community-based study of psychiatric and substance use disorders among a large, ethnically diverse cohort representative of young adults in South Florida. Adversity was estimated with a count of major and potentially traumatic events experienced during one's lifetime and prior to the onset of disorder. SETTING: Most interviews took place in the homes of participants, with 30% conducted by telephone. PARTICIPANTS: We obtained a random sample of individuals aged 18 to 23 years from a previously studied representative sample of young adolescents. Because participants in the prior study were predominantly boys, a supplementary sample of girls was randomly obtained from the early-adolescence school class rosters. A total of 1803 interviews were completed, representing a success rate of 70.1%. MAIN OUTCOME MEASURES: Depressive and anxiety disorders were assessed through computer-assisted personal interviews using the DSM-IV version of the Michigan Composite International Diagnostic Interview. RESULTS: Level of lifetime exposure to adversity was found to be associated with an increased risk of subsequent onset of depressive and/or anxiety disorder. This association remained clearly observable when childhood conduct disorder, attention-deficit/hyperactivity disorder, prior substance dependence, and posttraumatic stress disorder were held constant and when the possibility of state dependence effects was considered. CONCLUSION: Evidence suggests that high levels of lifetime exposure to adversity are causally implicated in the onset of depressive and anxiety disorders.
Authors: Carlos I Pérez Benítez; Shirley Yen; M Tracie Shea; Maria O Edelen; John C Markowitz; Thomas H McGlashan; Emily B Ansell; Carlos M Grilo; Andrew E Skodol; John G Gunderson; Leslie C Morey Journal: J Clin Psychol Date: 2010-06
Authors: Briana Mezuk; Jane A Rafferty; Kiarri N Kershaw; Darrell Hudson; Cleopatra M Abdou; Hedwig Lee; William W Eaton; James S Jackson Journal: Am J Epidemiol Date: 2010-09-30 Impact factor: 4.897
Authors: Kathryn E Gill; Ann M Chappell; Thomas J R Beveridge; Linda J Porrino; Jeffrey L Weiner Journal: Alcohol Clin Exp Res Date: 2014-08 Impact factor: 3.455