Antonio Galvao Neto1, Keyla Pineda-Daboin, Mario A Luna. 1. Department of Pathology and Laboratory Medicine, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.
Abstract
BACKGROUND: Extraglandular myoepitheliomas are neoplasms that seldom occur in the soft tissue of the head and neck region. Misdiagnosis of these neoplasms as more aggressive tumors can lead to unnecessary treatment. METHODS: We describe a myoepithelioma of cervical soft tissue. The histopathology of the tumor, its immunophenotype, its differential diagnosis, and a review of the literature are presented. RESULTS: Histopathologically, the tumor was composed of epithelioid cells with eosinophilic cytoplasm and eccentric nuclei arranged in cords and files. On immunohistochemical analysis, the cells expressed cytokeratin 14, calponin, glial fibrillary acid protein, and p63 and showed focal positivity for S-100 protein. Together, these markers identified the cells as myoepithelial type. A literature review identified only five cases of myoepithelioma in the soft tissue of the head and neck region in which detailed clinical information was provided. CONCLUSIONS: Myoepitheliomas can have cells with variable morphology arranged in different histologic patterns. Immunohistochemical analysis is crucial for unequivocal diagnosis when myoepitheliomas occur in extraglandular locations. Copyright 2004 Wiley Periodicals, Inc. Head Neck 26: 470-473, 2004
BACKGROUND: Extraglandular myoepitheliomas are neoplasms that seldom occur in the soft tissue of the head and neck region. Misdiagnosis of these neoplasms as more aggressive tumors can lead to unnecessary treatment. METHODS: We describe a myoepithelioma of cervical soft tissue. The histopathology of the tumor, its immunophenotype, its differential diagnosis, and a review of the literature are presented. RESULTS: Histopathologically, the tumor was composed of epithelioid cells with eosinophilic cytoplasm and eccentric nuclei arranged in cords and files. On immunohistochemical analysis, the cells expressed cytokeratin 14, calponin, glial fibrillary acid protein, and p63 and showed focal positivity for S-100 protein. Together, these markers identified the cells as myoepithelial type. A literature review identified only five cases of myoepithelioma in the soft tissue of the head and neck region in which detailed clinical information was provided. CONCLUSIONS:Myoepitheliomas can have cells with variable morphology arranged in different histologic patterns. Immunohistochemical analysis is crucial for unequivocal diagnosis when myoepitheliomas occur in extraglandular locations. Copyright 2004 Wiley Periodicals, Inc. Head Neck 26: 470-473, 2004
Authors: Vickie Y Jo; Cristina R Antonescu; Brendan C Dickson; David Swanson; Lei Zhang; Christopher D M Fletcher; Elizabeth G Demicco Journal: Am J Surg Pathol Date: 2019-10 Impact factor: 6.394
Authors: Vickie Y Jo; Cristina R Antonescu; Lei Zhang; Paola Dal Cin; Jason L Hornick; Christopher D M Fletcher Journal: Am J Surg Pathol Date: 2013-05 Impact factor: 6.394