BACKGROUND: Eisenmenger syndrome in pregnancy may be a life-threatening disease despite recent additions to the treatment options. CASE: We present a woman with severe pulmonary hypertension due to Eisenmenger syndrome treated during pregnancy and delivery and postpartum with L-arginine and sildenafil to enhance the nitric oxide pathway. This combination was associated with significant improvement in the mother's clinical and hemodynamic condition and fetal well-being. CONCLUSION: The concomitant use of sildenafil and L-arginine for the management of pulmonary hypertension in pregnancy, combined with multidisciplinary care, permitted a good outcome for the mother and her infant.
BACKGROUND:Eisenmenger syndrome in pregnancy may be a life-threatening disease despite recent additions to the treatment options. CASE: We present a woman with severe pulmonary hypertension due to Eisenmenger syndrome treated during pregnancy and delivery and postpartum with L-arginine and sildenafil to enhance the nitric oxide pathway. This combination was associated with significant improvement in the mother's clinical and hemodynamic condition and fetal well-being. CONCLUSION: The concomitant use of sildenafil and L-arginine for the management of pulmonary hypertension in pregnancy, combined with multidisciplinary care, permitted a good outcome for the mother and her infant.
Authors: Elizabeth Cottrell; Teresa Tropea; Laura Ormesher; Susan Greenwood; Mark Wareing; Edward Johnstone; Jenny Myers; Colin Sibley Journal: J Physiol Date: 2017-02-27 Impact factor: 5.182
Authors: Chrisen H Maharaj; Daniel O'Toole; Tadhg Lynch; John Carney; James Jarman; Brendan D Higgins; John J Morrison; John G Laffey Journal: Reprod Biol Endocrinol Date: 2009-04-23 Impact factor: 5.211